Tadalafil
Pulmonary Hypertension, Vasculogenic Impotence
DRUG STATUS
Approvals
US(FDA), UK(BNF)
Essential Medicine
NO
Teratogenicity
Unlisted
Pharmaceutical Class
Phosphodiesterase 5 Inhibitor
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Tadalafil
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Click HereSummary
Tadalafil is primarily used to treat erectile dysfunction (ED), which is difficulty in achieving and maintaining an erection. It is also used for benign prostatic hyperplasia (BPH), a condition that causes problems with urination. Additionally, it can treat pulmonary arterial hypertension (PAH), a type of high blood pressure that affects the arteries in the lungs and heart.
Tadalafil works by relaxing the blood vessels in the penis. This increases blood flow, helping men get and keep an erection. It also relaxes muscles in the prostate and bladder, which can make it easier to urinate for people with an enlarged prostate.
Tadalafil is taken orally, usually as a tablet. For erectile dysfunction, it can be used as needed or daily in smaller doses. For BPH, it's typically taken daily. If you're using it for on-demand use, take it 30 minutes to 1 hour before sexual activity. If you're taking a daily dose, you should take it at the same time every day.
Common side effects of Tadalafil include headache, back pain, muscle aches, indigestion, flushing, nasal congestion, and dizziness. Serious side effects can include a painful prolonged erection, sudden vision or hearing loss, chest pain, irregular heartbeats, and shortness of breath.
Tadalafil should be used with caution in people with heart problems, low blood pressure, severe kidney or liver impairment, and certain rare inherited eye diseases. It should not be combined with nitrates or certain other medications due to the risk of a dangerous drop in blood pressure.
Indications and Purpose
What is Tadalafil used for?
- Erectile Dysfunction (ED): Tadalafil helps men with ED to achieve and maintain an erection.
- Benign Prostatic Hyperplasia (BPH): It helps alleviate symptoms such as difficulty in urinating.
- Pulmonary Arterial Hypertension (PAH): Tadalafil can also be used to treat PAH by relaxing blood vessels in the lungs, improving exercise capacity.
How does Tadalafil work?
Tadalafil works by helping the blood vessels in the penis relax, allowing more blood to flow in, which helps men get and keep an erection. It also helps relax muscles in the prostate and bladder, making it easier to urinate for people with an enlarged prostate.
Is Tadalafil effective?
Tadalafil is considered effective for most people with ED, with many experiencing improvement in their ability to achieve and maintain an erection. It is also effective for treating the symptoms of BPH. However, individual responses can vary, and some may need to adjust the dose or explore other treatments based on their doctor's advice.
How does one know if Tadalafil is working?
You can tell that tadalafil is working if you experience the following:
- Improved erections (in case of erectile dysfunction) or the ability to maintain an erection long enough for sexual activity.
- Improved urinary symptoms (in case of benign prostatic hyperplasia), such as easier or more frequent urination.
- In some cases, you may also notice improved exercise capacity (for pulmonary arterial hypertension).
If you don't see improvement, consult your doctor to assess whether the dose needs adjustment or if a different treatment is necessary.
Directions for Use
How do I take Tadalafil?
- Tadalafil is taken orally, typically as a tablet. It can be taken with or without food.
- If you're using it for on-demand use, take it 30 minutes to 1 hour before sexual activity.
- If you're taking a daily dose, you should take it at the same time every day, regardless of whether you plan to have sex.
For how long do I take Tadalafil?
- The duration of use depends on the specific condition you're treating.
- For erectile dysfunction: It can be used as needed (on-demand) or daily (in smaller doses).
- For BPH: It’s typically taken on a daily basis for long-term use.
- Always follow your healthcare provider's instructions on how long to use the medication.
How long does it take for Tadalafil to start working?
- For ED: Tadalafil typically starts working within 30 minutes to 1 hour, but it can take longer for some individuals.
- For BPH: It may take up to 1-2 weeks to feel the full effect.
How should I store Tadalafil?
- Store tadalafil at room temperature (between 68°F and 77°F or 20°C to 25°C).
- Keep it in its original container, tightly closed, and out of reach of children.
- Do not store it in a damp place (like a bathroom) or near heat sources
Warnings and Precautions
Who should avoid taking Tadalafil?
- People with heart problems: Those with a history of heart attack, stroke, or severe heart or liver problems should consult their doctor before using tadalafil.
- People with low blood pressure (hypotension): Tadalafil can lower blood pressure, and it should be used cautiously in individuals with low blood pressure.
- People taking nitrates (e.g., nitroglycerin): The combination can cause a dangerous drop in blood pressure.
- People with severe kidney or liver impairment: Tadalafil may need to be adjusted or avoided in these cases.
- People with certain rare inherited eye diseases (e.g., retinitis pigmentosa).
Can I take Tadalafil with other prescription drugs?
- Interactions to be cautious about:
- Nitrates: Combining tadalafil with nitrates (e.g., nitroglycerin) can cause a dangerous drop in blood pressure.
- Alpha-blockers (e.g., for high blood pressure or prostate issues): Using tadalafil with alpha-blockers can also lower blood pressure too much.
- Certain antifungals and antibiotics (e.g., ketoconazole, clarithromycin): These may increase the levels of tadalafil in your bloodstream.
- HIV protease inhibitors: These can also affect how your body processes tadalafil.
It’s important to inform your doctor about all medications you are taking, including over-the-counter drugs, prescription drugs, and herbal supplements, to avoid potential interactions.
Can I take Tadalafil with vitamins or supplements?
Tadalafil can be taken with most vitamins and supplements. However, you should be cautious with supplements that affect blood pressure, such as nitric oxide boosters, ginseng, or certain herbal remedies. Always check with your healthcare provider before combining tadalafil with supplements to avoid any potential interactions or side effects.
Can Tadalafil be taken safely while pregnant?
Tadalafil is not recommended for use during pregnancy because its safety in pregnant women has not been established.
Can Tadalafil be taken safely while breastfeeding?
Tadalafil is not recommended for use while breastfeeding because its effects on breastfeeding and infants are not well studied. If you are breastfeeding, consult your healthcare provider for alternative treatment options.
Is Tadalafil safe for the elderly?
Tadalafil can be safe for elderly individuals when prescribed by a doctor, but the dose may need to be adjusted, especially if the person has other health issues such as kidney or liver problems. Older adults are also more sensitive to changes in blood pressure, so careful monitoring is recommended.
Is it safe to exercise while taking Tadalafil?
Exercise is generally safe while taking tadalafil. In fact, staying physically active may help improve your overall health and reduce symptoms of erectile dysfunction or benign prostatic hyperplasia. However, if you experience dizziness, chest pain, or other unusual symptoms while exercising, stop and seek medical advice.
Is it safe to drink alcohol while taking Tadalafil?
Drinking alcohol in moderation is generally safe while taking tadalafil. However, excessive alcohol consumption can increase the risk of side effects like dizziness or fainting. Alcohol can also interfere with your ability to get an erection, so it's best to use caution.