Clonazepam
Myoclonic Epilepsies, Absence Epilepsy ... show more
DRUG STATUS
Approvals
US(FDA), UK(BNF)
Essential Medicine
YES
Teratogenicity
Unlisted
Pharmaceutical Class
Benzodiazepine
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Clonazepam
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Click HereSummary
Clonazepam is used to treat seizure disorders such as epilepsy in both adults and children. It can also be used to treat panic disorder with or without fear of open spaces, known as agoraphobia, in adults.
Clonazepam works by increasing the levels of GABA, a neurotransmitter that calms down brain activity. This results in reduced anxiety and seizure activity.
Clonazepam is typically taken orally, with or without food, 1 to 3 times a day. The starting dose is usually 0.5 mg to 1 mg once a day, which can be gradually increased by 0.5 mg to 1 mg every 3 days until the desired effect is achieved. The maximum recommended daily dose is 4 mg.
Common side effects of Clonazepam include drowsiness and dizziness. Serious adverse effects can include seizures and suicidal thoughts.
Clonazepam should not be taken by pregnant women or breastfeeding mothers unless the benefits outweigh the risks. It can cause allergic reactions, dependence and withdrawal symptoms if stopped suddenly. It can also increase the risk of suicidal thoughts, especially in patients with a history of depression or suicidal behavior.
Indications and Purpose
What is Clonazepam used for?
Clonazepam is a medication used to treat seizures (epilepsy) in both adults and children. It can also be used to treat panic disorder with or without fear of open spaces (agoraphobia) in adults. Clonazepam works by slowing down the electrical activity in the brain, which helps to prevent seizures and reduce anxiety.
How does Clonazepam work?
Clonazepam works by increasing the level of GABA, a neurotransmitter that calms down brain activity, resulting in reduced seizure and anxiety activity.
Is Clonazepam effective?
Clonazepam has been shown to be effective in reducing seizures in patients with epilepsy, and improving symptoms of anxiety disorders.
How does one know if Clonazepam is working?
Patients should monitor their symptoms and report any changes to their healthcare provider. This can help the provider to determine if the medication is working effectively.
Regular follow-up appointments with a healthcare provider can help to monitor the patient's response to Clonazepam and make any necessary adjustments to the dosage.
Patients may also be asked to complete self-assessment questionnaires to measure the severity of their symptoms before and after taking Clonazepam.
Directions for Use
What is the usual dose of Clonazepam?
**For Adults with Seizures:** * Start with a low dose of 1.5 mg per day, taken in three doses. * Gradually increase the dose by 0.5-1 mg every 3 days. * Don't take more than 20 mg per day. **For Adults with Panic Disorder:** * Start with 0.25 mg twice a day. * Increase to 1 mg per day after 3 days. * Some people may need up to 4 mg per day. **For Children (under 10 years or 66 pounds):** * Start with a very low dose of 0.01-0.03 mg per kg of body weight per day. * Don't give more than 0.05 mg per kg per day. * Split the dose into two or three smaller doses. * Gradually increase the dose by 0.25-0.5 mg every 3 days. * Don't give more than 0.1-0.2 mg per kg per day.
How do I take Clonazepam?
Clonazepam can be taken with or without food, but it is best to take it consistently at the same time each day.
If you are taking the liquid form of Clonazepam, use the measuring spoon or cup provided to accurately measure the dose.
Clonazepam can cause drowsiness, dizziness, and impaired judgment. Do not operate heavy machinery or drive a motor vehicle while taking Clonazepam.
For how long do I take Clonazepam?
Clonazepam is a medication that has been studied for use for up to 9 weeks. It's not clear how well it works for longer than that. If you need to take clonazepam for longer than 9 weeks, your doctor should check in with you regularly to make sure it's still working and that you're not having any problems from taking it.
How long does it take for Clonazepam to start working?
Clonazepam starts to work within 1 to 4 hours after taking a dose. However, it may take several weeks for the full effects of Clonazepam to be felt, and for the medication to reach a stable concentration in the body.
Patients taking Clonazepam should monitor their symptoms and report any changes to their healthcare provider. The dose of Clonazepam may need to be adjusted based on the patient's response to the medication.
How should I store Clonazepam?
Keep your Clonazepam between 59°F to 86°F (15°C to 30°C) and make sure to keep all medicines away from children.
Warnings and Precautions
Who should avoid taking Clonazepam?
Allergic reactions: Clonazepam can cause serious allergic reactions, including rash, hives, and difficulty breathing.
Dependence and withdrawal: Clonazepam can be habit-forming and can cause physical dependence. Stopping the medication suddenly can cause withdrawal symptoms.
Suicidal thoughts: In some patients, Clonazepam can increase the risk of suicidal thoughts, especially in patients with a history of depression or suicidal behavior.
Can I take Clonazepam with other prescription drugs?
Opioids: Taking Clonazepam with opioids can increase the risk of drowsiness, dizziness, and respiratory depression.
Antihistamines: Taking Clonazepam with antihistamines can increase the sedative effects of both medications and may cause excessive drowsiness.
Sedatives: Taking Clonazepam with sedatives can increase the risk of drowsiness and impairment.
Can I take Clonazepam with vitamins or supplements?
St. John's Wort: This herbal supplement can reduce the effectiveness of Clonazepam by increasing its breakdown in the liver.
Valerian root: This herbal supplement can increase the sedative effects of Clonazepam and may cause excessive drowsiness.
Vitamin B12: This vitamin can increase the breakdown of Clonazepam, which can reduce its effectiveness.
Can Clonazepam be taken safely while pregnant?
Clonazepam is classified as a Pregnancy Category D drug and can cause harm to a developing fetus. Pregnant women should avoid taking Clonazepam unless the potential benefits outweigh the potential risks.
Can Clonazepam be taken safely while breastfeeding?
Breastfeeding mothers should avoid taking Clonazepam unless the potential benefits outweigh the potential risks to the infant.
Is Clonazepam safe for the elderly?
For older adults, start with a low dose of clonazepam and watch them closely. This is because their liver and kidneys may not work as well, which can affect how much medicine they need. Clonazepam can make people feel sleepy and confused, so it's important to monitor them carefully. There isn't much research on using clonazepam in older adults with seizures.
Is it safe to exercise while taking Clonazepam?
Exercise is generally safe while taking clonazepam, but due to its sedative effects, you may feel more tired or less coordinated. It's important to avoid intense physical activities until you understand how the medication affects your body. Always talk to your doctor about your exercise plans while on this medicine.
Is it safe to drink alcohol while taking Clonazepam?
Drinking alcohol with clonazepam can be dangerous because it enhances drowsiness and can affect breathing. This combination may lead to severe side effects, such as dizziness, fainting, or even loss of consciousness. It's best to avoid alcohol while taking this medication. Always consult your doctor before combining them.