Tranylcypromine
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Monoamine Oxidase Inhibitor
Controlled Drug Substance
No
tranylcypromine
Summary
Tranylcypromine is used to treat major depressive disorder, which is a severe form of depression causing persistent sadness and loss of interest in activities. It may also be used for other conditions as determined by your doctor.
Tranylcypromine works by inhibiting an enzyme called monoamine oxidase, which breaks down chemicals in the brain like serotonin and norepinephrine. By blocking this enzyme, it increases these chemicals, improving mood and relieving depression symptoms.
The usual starting dose for adults is 30 mg per day, divided into two doses. The maximum recommended dose is 60 mg per day. It's taken orally, usually twice daily, in the morning and afternoon, with or without food.
Common side effects include dizziness, dry mouth, and insomnia, which is difficulty sleeping. These effects vary in frequency and severity and are usually mild to moderate.
Tranylcypromine can cause high blood pressure and has major interactions with other antidepressants. It's contraindicated in people with a history of stroke or severe liver disease. Avoid certain foods and drinks like aged cheese and red wine.
Indications and Purpose
How does Tranylcypromine work?
Tranylcypromine works by inhibiting an enzyme called monoamine oxidase, which breaks down certain chemicals in the brain like serotonin and norepinephrine. By blocking this enzyme, Tranylcypromine increases the levels of these chemicals, which can help improve mood and relieve symptoms of depression. Think of it like a dam holding back water; the medication prevents the breakdown of mood-enhancing chemicals, allowing them to build up and improve your mood. This effect makes Tranylcypromine helpful for people with depression, which is a mood disorder causing persistent sadness.
Is Tranylcypromine effective?
Yes, Tranylcypromine is effective for treating depression, which is a mood disorder causing persistent feelings of sadness and loss of interest. It works by increasing the levels of certain chemicals in the brain that help improve mood. Clinical studies show that Tranylcypromine can significantly reduce symptoms of depression in many patients. However, its effectiveness can vary from person to person. It's important to take Tranylcypromine exactly as prescribed by your doctor to achieve the best results. Regular follow-ups with your doctor can help monitor your progress and adjust treatment if needed.
What is Tranylcypromine?
Tranylcypromine is a medication used to treat depression, which is a mood disorder causing persistent sadness. It belongs to a class of drugs called monoamine oxidase inhibitors (MAOIs), which work by increasing the levels of certain chemicals in the brain that help improve mood. Tranylcypromine is primarily indicated for treating major depressive disorder, which is a severe form of depression. It may also be used for other conditions as determined by your doctor. It's important to take Tranylcypromine exactly as prescribed to manage your condition effectively.
Directions for Use
For how long do I take Tranylcypromine?
Tranylcypromine is usually a long-term medication for managing depression, which is a mood disorder causing persistent sadness. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. The duration of use depends on your body's response, any side effects you experience, and changes in your overall health. Stopping this medication without medical advice could cause your condition to worsen. Always talk with your doctor before changing or stopping your Tranylcypromine treatment. They can guide you on the best course of action for your health.
How do I dispose of Tranylcypromine?
To dispose of Tranylcypromine, take it to a drug take-back program or collection site at a pharmacy or hospital. These programs ensure the medication is disposed of properly, preventing harm to people or the environment. If you can't find a take-back program, you can throw the medication in the trash at home. First, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away. This helps prevent accidental ingestion by children or pets.
How do I take Tranylcypromine?
Take Tranylcypromine exactly as your doctor prescribes. Usually, it's taken twice daily, in the morning and afternoon. You can take it with or without food. Do not crush or chew the tablets. Avoid certain foods and drinks like aged cheese and red wine, which can interact with the medicine. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose. Never double up on doses. Always follow your doctor's specific instructions for the best results.
How long does it take for Tranylcypromine to start working?
Tranylcypromine may start to work within a few days, but it can take several weeks to achieve its full therapeutic effect. The time it takes to notice improvements can vary depending on individual factors like your body's response and the severity of your depression. Some people might feel better within two weeks, while others may take longer. It's important to take Tranylcypromine exactly as prescribed and continue using it even if you don't notice immediate improvements. Regular follow-ups with your doctor can help monitor your progress and adjust treatment if needed.
How should I store Tranylcypromine?
Store Tranylcypromine at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Avoid storing it in humid places like bathrooms, where moisture in the air could affect how well the medication works. If your pills came in packaging that isn't child-resistant, transfer them to a container that children can't easily open. Always store Tranylcypromine out of children's reach to prevent accidental swallowing. Remember to check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Tranylcypromine?
The usual starting dose of Tranylcypromine for adults is 30 mg per day, divided into two doses. Your doctor may adjust the dose based on your response and needs. The maximum recommended dose is 60 mg per day. Dose adjustments may be necessary for elderly patients or those with certain health conditions. Always follow your doctor's specific dosing instructions for your personal health needs. It's important to take Tranylcypromine exactly as prescribed to manage your condition effectively.
Warnings and Precautions
Can I take Tranylcypromine with other prescription drugs?
Tranylcypromine has major drug interactions with other antidepressants, especially SSRIs and SNRIs, which can lead to serotonin syndrome, a potentially life-threatening condition. It also interacts with certain pain medications like tramadol, increasing the risk of side effects. Moderate interactions include over-the-counter cold medications containing decongestants, which can raise blood pressure. These interactions can increase the risk of adverse effects or reduce the effectiveness of Tranylcypromine. Always inform your doctor about all medications you're taking to avoid harmful interactions and ensure safe and effective treatment.
Can Tranylcypromine be taken safely while breastfeeding?
Tranylcypromine is not recommended while breastfeeding due to limited information on its safety. We don't know if it passes into human breast milk or its effects on a breastfed infant. Animal studies suggest it might appear in milk, raising concerns about potential risks to a baby's development. If you're taking Tranylcypromine and want to breastfeed, talk with your doctor about safer medication options. They can help you find a treatment that allows you to nurse your baby safely while managing your health condition.
Can Tranylcypromine be taken safely while pregnant?
Tranylcypromine is not recommended during pregnancy due to limited evidence on its safety. Animal studies suggest potential risks, but we lack comprehensive human data. Uncontrolled depression during pregnancy can cause serious problems for both mother and baby, including preterm birth and low birth weight. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your depression. Your doctor can help create a treatment plan that protects both you and your baby, possibly suggesting alternative medications or therapies.
Does Tranylcypromine have adverse effects?
Yes, Tranylcypromine can have adverse effects, which are unwanted reactions to a medication. Common adverse effects include dizziness, dry mouth, and insomnia, which is difficulty sleeping. These effects vary in frequency and severity. Serious side effects can include high blood pressure and serotonin syndrome, which is a potentially life-threatening condition caused by too much serotonin in the brain. If you notice any new or worsening symptoms, contact your doctor immediately. They can help determine if the symptoms are related to Tranylcypromine and provide appropriate treatment.
Does Tranylcypromine have any safety warnings?
Yes, Tranylcypromine has important safety warnings. It can cause high blood pressure, which is a serious condition where the force of the blood against your artery walls is too high. This can lead to severe headaches, chest pain, or blurred vision. Not following safety warnings can result in dangerous health issues. Avoid certain foods and drinks like aged cheese and red wine, which can interact with the medicine. Always follow your doctor's advice and report any unusual symptoms immediately to ensure safe use of Tranylcypromine.
Is it safe to drink alcohol while taking Tranylcypromine?
It's best to avoid alcohol while taking Tranylcypromine. Alcohol can increase the risk of side effects like dizziness and drowsiness, which are feelings of being sleepy or lightheaded. It can also interfere with the effectiveness of the medication. Drinking alcohol while on Tranylcypromine can lead to dangerous interactions, such as high blood pressure or serotonin syndrome, which is a potentially life-threatening condition. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs. Talk with your doctor about alcohol use while taking Tranylcypromine for personalized advice.
Is it safe to exercise while taking Tranylcypromine?
Yes, you can exercise while taking Tranylcypromine, but be cautious. This medication can cause dizziness or changes in blood pressure, which might affect your ability to exercise safely. Start with light to moderate activities and see how your body responds. Drink plenty of water to stay hydrated and avoid strenuous activities or high-impact sports until you know how the medication affects you. If you feel dizzy or lightheaded during exercise, stop and rest. Talk with your doctor about your exercise routine to ensure it's safe while taking Tranylcypromine.
Is it safe to stop Tranylcypromine?
No, it's not safe to stop Tranylcypromine suddenly. This medication is usually used long-term for managing conditions like depression. Stopping it abruptly can cause withdrawal symptoms, which are unpleasant physical or mental effects that occur when you stop taking a drug. These symptoms might include anxiety, confusion, or sleep problems. Always talk with your doctor before stopping Tranylcypromine. They might suggest gradually reducing your dose to prevent withdrawal symptoms and keep your condition under control. Your doctor will help you make any medication changes safely.
Is Tranylcypromine addictive?
Tranylcypromine is not considered addictive in the traditional sense, but it can lead to physical dependence. This means your body might get used to the medication, and stopping it suddenly can cause withdrawal symptoms. These symptoms might include anxiety, confusion, or sleep problems. To prevent dependence, follow your doctor's instructions carefully and do not stop taking Tranylcypromine abruptly. If you need to stop the medication, your doctor will guide you on how to do it safely, usually by gradually reducing the dose.
Is Tranylcypromine safe for the elderly?
The elderly are more vulnerable to safety risks with Tranylcypromine due to age-related changes in the body. These changes can affect how the medication is processed, increasing the risk of side effects like dizziness and high blood pressure. Tranylcypromine can be used in the elderly, but with caution. Doctors may start with a lower dose and monitor closely for any adverse effects. It's important for elderly patients to have regular check-ups to ensure the medication is working safely and effectively. Always follow your doctor's advice when taking Tranylcypromine.
What are the most common side effects of Tranylcypromine?
Common side effects of Tranylcypromine include dizziness, dry mouth, and insomnia, which is difficulty sleeping. These side effects are unwanted reactions that can happen when taking a medication. They vary from person to person and are usually mild to moderate in severity. If you experience these side effects, they might be temporary or unrelated to the medication. It's important to talk with your doctor before stopping any medication. They can help determine if the side effects are related to Tranylcypromine and suggest ways to manage them.
Who should avoid taking Tranylcypromine?
Tranylcypromine has important contraindications, which are situations where the drug should not be used. Absolute contraindications include having a history of stroke or severe liver disease. Relative contraindications, where caution is needed, include high blood pressure or taking certain medications like other antidepressants. Using Tranylcypromine in these situations can lead to severe risks, such as dangerously high blood pressure or serotonin syndrome, which is a potentially life-threatening condition. Always consult your doctor about your medical history and current medications before starting Tranylcypromine to ensure it's safe for you.
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