Talazoparib
Breast Neoplasms
.svg)
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Poly(ADP-Ribose) Polymerase Inhibitor
Controlled Drug Substance
No
Talazoparib
Summary
Talazoparib is used to treat certain types of breast and prostate cancer. Specifically, it's used for breast cancers that are HER2-negative with specific genetic mutations and for metastatic castration-resistant prostate cancers with HRR gene mutations.
Talazoparib works by blocking PARP enzymes that help in DNA repair. This prevents cancer cells from repairing their DNA, leading to cell death. It is especially effective in cancers with certain genetic mutations that already impair DNA repair processes.
For adults with breast cancer, the usual daily dose of Talazoparib is 1 mg taken orally once daily. For adults with prostate cancer, the dose is 0.5 mg taken orally once daily in combination with enzalutamide.
Common side effects of Talazoparib include fatigue, nausea, anemia, neutropenia, and thrombocytopenia. Other side effects can include decreased appetite, headaches, gastrointestinal issues like vomiting and diarrhea, weight loss, and dizziness.
Talazoparib can cause serious conditions like myelodysplastic syndrome/acute myeloid leukemia and severe myelosuppression. It can also harm the fetus, so it's not recommended for pregnant women. Patients should use effective contraception during treatment and for a period after the last dose. It's important to consult with a healthcare provider before starting or stopping any medication.
Indications and Purpose
How does Talazoparib work?
Talazoparib works by inhibiting a protein called PARP, which helps repair damaged DNA in cells. Think of it like blocking a repair crew from fixing a broken bridge. By preventing DNA repair, Talazoparib helps kill cancer cells, particularly those with BRCA mutations. This action makes Talazoparib effective in treating certain types of breast cancer by slowing cancer progression.
Is Talazoparib effective?
Talazoparib is effective in treating certain types of breast cancer, particularly those with BRCA mutations. It works by inhibiting a protein called PARP, which helps repair damaged DNA in cancer cells. By blocking this repair process, Talazoparib helps kill cancer cells. Clinical studies show Talazoparib can slow cancer progression and improve survival rates in patients with BRCA-mutated breast cancer.
What is Talazoparib?
Talazoparib is a medication used to treat certain types of breast cancer, particularly those with BRCA mutations. It belongs to a class of drugs called PARP inhibitors, which block a protein that helps repair damaged DNA in cancer cells. By preventing this repair, Talazoparib helps kill cancer cells. It's used as a complementary addition to other therapies in cancer treatment.
Directions for Use
For how long do I take Talazoparib?
Talazoparib is usually taken long-term for managing certain types of breast cancer. The duration of use depends on your response to treatment and any side effects you experience. Your doctor will determine how long you need to take Talazoparib based on your specific health needs. Always talk with your doctor before changing or stopping your Talazoparib treatment.
How do I dispose of Talazoparib?
Dispose of Talazoparib by taking it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away in the trash.
How do I take Talazoparib?
Take Talazoparib once daily, at the same time each day, with or without food. Swallow the capsule whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose. Do not take two doses at once. Follow your doctor's specific instructions regarding any dietary or beverage restrictions while on this medication.
How long does it take for Talazoparib to start working?
Talazoparib starts working in your body shortly after you take it, but the full therapeutic effect may take weeks to months. The time it takes to see results can vary based on individual factors like your cancer type and overall health. Regular check-ups and imaging tests with your doctor will help monitor your progress and determine how well Talazoparib is working for you.
How should I store Talazoparib?
Store Talazoparib at room temperature, away from moisture and light. Keep it in a tightly closed container. Avoid storing it in humid places like bathrooms, as moisture can affect the medication's effectiveness. Always store Talazoparib out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Talazoparib?
The usual starting dose of Talazoparib for adults is 1 mg taken once daily. Your doctor may adjust your dose based on your response and any side effects. The maximum recommended dose is 1 mg per day. Always follow your doctor's specific dosing instructions for your personal health needs. Dose adjustments may be necessary for special populations, such as those with kidney problems.
Warnings and Precautions
Can I take Talazoparib with other prescription drugs?
Talazoparib can interact with certain medications, increasing the risk of side effects or reducing effectiveness. Strong inhibitors of CYP3A, a liver enzyme, can increase Talazoparib levels, leading to more side effects. Always inform your doctor about all medications you take to avoid interactions. Your doctor may adjust your dose or suggest alternatives to manage potential interactions safely.
Can Talazoparib be taken safely while breastfeeding?
Talazoparib is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. However, it may pose risks to a breastfed infant. If you're taking Talazoparib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Talazoparib be taken safely while pregnant?
Talazoparib is not recommended during pregnancy. It can harm an unborn baby. Animal studies show potential risks, but we lack sufficient human data. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options. Your doctor can help create a pregnancy-specific plan to protect both you and your baby.
Does Talazoparib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Talazoparib include fatigue, nausea, and low blood cell counts. These effects vary in frequency and severity. Serious side effects include bone marrow suppression, which requires immediate medical attention. Always inform your doctor about any new or worsening symptoms while taking Talazoparib to ensure safe and effective treatment.
Does Talazoparib have any safety warnings?
Yes, Talazoparib has important safety warnings. It can cause bone marrow suppression, which affects blood cell production, leading to anemia or low white blood cell counts. This increases infection risk. Regular blood tests are needed to monitor your blood cell levels. If you experience unusual bruising, bleeding, or signs of infection, contact your doctor immediately. Adhering to safety warnings helps prevent serious complications.
Is it safe to drink alcohol while taking Talazoparib?
It's best to avoid alcohol while taking Talazoparib. Alcohol can increase the risk of side effects like dizziness or nausea. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like dizziness or stomach upset. Talk with your doctor about alcohol use while taking Talazoparib to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Talazoparib?
You can exercise while taking Talazoparib, but be cautious. This medication can cause fatigue, which might affect your exercise capacity. Listen to your body and avoid strenuous activities if you feel tired. To exercise safely, stay hydrated and watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest.
Is it safe to stop Talazoparib?
Stopping Talazoparib suddenly can affect your treatment's effectiveness. If you're taking it for cancer, stopping could allow the cancer to progress. Always talk with your doctor before stopping Talazoparib. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely.
Is Talazoparib addictive?
Talazoparib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Talazoparib works by targeting cancer cells and doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Talazoparib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Talazoparib, such as fatigue and low blood cell counts. Regular monitoring by a healthcare provider is important to manage these risks. Talazoparib can be used safely in the elderly with careful dose adjustments and monitoring. Always consult your doctor about any concerns specific to elderly patients.
What are the most common side effects of Talazoparib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Talazoparib include fatigue, nausea, and low blood cell counts. These effects vary from person to person. If you notice new symptoms after starting Talazoparib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Talazoparib?
Do not take Talazoparib if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Talazoparib is not recommended for people with severe liver or kidney problems, as it may worsen these conditions. Always consult your doctor about any concerns or pre-existing conditions before starting Talazoparib.
