Sacubitril + Valsartan

Find more information about this combination medication at the webpages for valsartan

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Brand Name

Sacutan 24mg/26mg Tablet 30s , Vymada 50mg Tablet 14s ... show more

Approved Treatment Indication:

Hypertension , Left Ventricular Dysfunction ... show more

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What conditions sacubitril and valsartan is used for
Sacubitril and valsartan are used to treat heart failure, which is a condition where the heart can't pump blood effectively. This combination helps improve heart function and reduce symptoms like shortness of breath and fatigue. It is also used to lower the risk of hospitalization and death in people with chronic heart failure. By relaxing blood vessels and reducing blood pressure, it helps the heart work more efficiently.
How sacubitril and valsartan works in the body
Sacubitril is a neprilysin inhibitor, which means it increases levels of proteins that help relax blood vessels. Valsartan is an angiotensin receptor blocker, which means it blocks substances that tighten blood vessels. Together, they help blood vessels relax, reducing blood pressure and making it easier for the heart to pump blood. This combination helps manage heart failure and improve overall heart health.
The usual dosages and routes of administration of sacubitril and valsartan
The usual adult daily dose of sacubitril and valsartan varies based on individual needs and medical conditions. Typically, the starting dose is 49 mg of sacubitril and 51 mg of valsartan, taken twice daily. The dose may be adjusted by a healthcare provider based on response and tolerance. It's important to follow the prescribed dosage and not to adjust it without consulting a healthcare provider. Regular monitoring helps ensure the medication is working effectively and safely.
The most commonly observed adverse effects of sacubitril and valsartan
Common side effects of sacubitril and valsartan include dizziness, which is a feeling of lightheadedness, and cough. These occur because the medicines lower blood pressure and affect the respiratory system. Significant adverse effects can include kidney problems and high potassium levels, which can affect heart rhythm. Sacubitril may cause angioedema, which is swelling under the skin, while valsartan can lead to low blood pressure. Monitoring by a healthcare provider is important to manage these effects.
Important safety warnings and contraindications of sacubitril and valsartan
Important warnings for sacubitril and valsartan include the risk of angioedema, which is swelling under the skin, and high potassium levels, which can affect heart rhythm. It's contraindicated in pregnancy due to potential harm to the fetus. People with a history of angioedema or severe kidney problems should avoid this medication. Regular monitoring of blood pressure, kidney function, and potassium levels is essential. Patients should inform their healthcare provider of any other medications or conditions to avoid complications.

Government Approvals

US(FDA)

WHO Essential Medicine

YES

Known Teratogen

Pharmaceutical Class

Angiotensin 2 Receptor Blocker

Controlled Drug Substance

Summary

What conditions sacubitril and valsartan is used for
Sacubitril and valsartan are used to treat heart failure, which is a condition where the heart can't pump blood effectively. This combination helps improve heart function and reduce symptoms like shortness of breath and fatigue. It is also used to lower the risk of hospitalization and death in people with chronic heart failure. By relaxing blood vessels and reducing blood pressure, it helps the heart work more efficiently.
How sacubitril and valsartan works in the body
Sacubitril is a neprilysin inhibitor, which means it increases levels of proteins that help relax blood vessels. Valsartan is an angiotensin receptor blocker, which means it blocks substances that tighten blood vessels. Together, they help blood vessels relax, reducing blood pressure and making it easier for the heart to pump blood. This combination helps manage heart failure and improve overall heart health.
The usual dosages and routes of administration of sacubitril and valsartan
The usual adult daily dose of sacubitril and valsartan varies based on individual needs and medical conditions. Typically, the starting dose is 49 mg of sacubitril and 51 mg of valsartan, taken twice daily. The dose may be adjusted by a healthcare provider based on response and tolerance. It's important to follow the prescribed dosage and not to adjust it without consulting a healthcare provider. Regular monitoring helps ensure the medication is working effectively and safely.
The most commonly observed adverse effects of sacubitril and valsartan
Common side effects of sacubitril and valsartan include dizziness, which is a feeling of lightheadedness, and cough. These occur because the medicines lower blood pressure and affect the respiratory system. Significant adverse effects can include kidney problems and high potassium levels, which can affect heart rhythm. Sacubitril may cause angioedema, which is swelling under the skin, while valsartan can lead to low blood pressure. Monitoring by a healthcare provider is important to manage these effects.
Important safety warnings and contraindications of sacubitril and valsartan
Important warnings for sacubitril and valsartan include the risk of angioedema, which is swelling under the skin, and high potassium levels, which can affect heart rhythm. It's contraindicated in pregnancy due to potential harm to the fetus. People with a history of angioedema or severe kidney problems should avoid this medication. Regular monitoring of blood pressure, kidney function, and potassium levels is essential. Patients should inform their healthcare provider of any other medications or conditions to avoid complications.

Indications and Purpose

How does combination of sacubitril and valsartan work?

Sacubitril and valsartan work together to improve heart function and lower blood pressure. Sacubitril is a neprilysin inhibitor, which means it increases levels of proteins that help relax blood vessels. Valsartan is an angiotensin receptor blocker, which means it blocks substances that tighten blood vessels. Together, they help blood vessels relax, reducing blood pressure and making it easier for the heart to pump blood. This combination helps manage heart failure and improve overall heart health.

How does combination of Sacubitril and Valsartan work?

The combination of Sacubitril and Valsartan is used to treat heart failure. Sacubitril works by blocking a substance in the body that breaks down natural substances that open up blood vessels. This helps to lower blood pressure and reduce the strain on the heart. Valsartan is an angiotensin receptor blocker (ARB) that helps relax blood vessels, which also lowers blood pressure and improves blood flow. Together, they help the heart pump more efficiently and reduce the risk of hospitalization for heart failure.

How effective is combination of sacubitril and valsartan?

Evidence for the effectiveness of sacubitril and valsartan comes from clinical trials showing improved heart function and reduced hospitalizations for heart failure. Sacubitril increases levels of proteins that help relax blood vessels, while valsartan blocks substances that cause blood vessels to tighten. Together, they lower blood pressure and improve heart efficiency. Studies have shown that this combination reduces the risk of death and hospitalization in people with heart failure compared to other treatments, proving its effectiveness in managing the condition.

How effective is combination of Sacubitril and Valsartan?

The combination of Sacubitril and Valsartan is effective in treating heart failure. According to the NHS, this combination helps to relax blood vessels, making it easier for the heart to pump blood around the body. This can lead to a reduction in the risk of hospitalization and death from heart failure. Sacubitril works by increasing the levels of certain proteins that help dilate blood vessels, while Valsartan blocks substances that tighten blood vessels. Together, they improve heart function and reduce symptoms of heart failure.

Directions for Use

What is the usual dose of combination of sacubitril and valsartan?

The usual adult daily dose of sacubitril and valsartan varies based on individual needs and medical conditions. Typically, the starting dose is 49 mg of sacubitril and 51 mg of valsartan, taken twice daily. The dose may be adjusted by a healthcare provider based on response and tolerance. It's important to follow the prescribed dosage and not to adjust it without consulting a healthcare provider. Regular monitoring helps ensure the medication is working effectively and safely.

What is the usual dose of combination of Sacubitril and Valsartan?

The usual starting dose of the combination of Sacubitril and Valsartan is typically 49 mg of Sacubitril and 51 mg of Valsartan, taken twice a day. Depending on how well the body tolerates the medication, the dose may be increased to 97 mg of Sacubitril and 103 mg of Valsartan, also taken twice daily. It's important to follow the healthcare provider's instructions and not adjust the dose without consulting them.

How does one take combination of sacubitril and valsartan?

Sacubitril and valsartan can be taken with or without food, but it's important to take it consistently the same way each time. Patients should avoid potassium-rich foods and salt substitutes containing potassium to prevent high potassium levels. It's crucial to follow the healthcare provider's instructions and not to change the dosage or stop the medication without consulting them. Regular monitoring of blood pressure and kidney function is recommended to ensure safe and effective use.

How does one take combination of Sacubitril and Valsartan?

The combination of Sacubitril and Valsartan is taken orally in the form of a tablet. It is usually prescribed to be taken twice a day, with or without food. It's important to follow the dosage instructions provided by your healthcare provider. Sacubitril and Valsartan work together to help relax blood vessels, making it easier for the heart to pump blood and reducing blood pressure. Sacubitril is a type of medication called a neprilysin inhibitor, which helps to increase levels of certain proteins that relax blood vessels. Valsartan is an angiotensin receptor blocker (ARB) that also helps to relax blood vessels by blocking the action of a hormone that causes blood vessels to tighten. Before starting this medication, inform your doctor about any other medications you are taking and any medical conditions you have, as this combination can interact with other drugs and may not be suitable for everyone. Regular monitoring by your healthcare provider is important to ensure the medication is working effectively and to adjust the dose if necessary.

For how long is combination of sacubitril and valsartan taken?

The typical duration of use for sacubitril and valsartan is long-term, as it is used to manage chronic heart failure. Patients usually continue taking it as prescribed by their healthcare provider to maintain heart function and control symptoms. Regular follow-ups with a healthcare provider are important to monitor the effectiveness and adjust the treatment as needed. It's essential not to stop the medication without consulting a healthcare provider, as this could worsen heart failure symptoms.

For how long is combination of Sacubitril and Valsartan taken?

The combination of Sacubitril and Valsartan is typically taken as a long-term treatment. It is used to manage chronic heart failure, which is a long-lasting condition. Patients usually continue taking it as prescribed by their healthcare provider to help control their symptoms and improve heart function. It's important to follow the doctor's instructions and not stop taking the medication without consulting them, as doing so could worsen the condition.

How long does it take for combination of sacubitril and valsartan to work?

Sacubitril and valsartan, when combined, start working within a few hours. Sacubitril, which is a neprilysin inhibitor, helps to increase levels of certain proteins that relax blood vessels. Valsartan, which is an angiotensin receptor blocker, helps to lower blood pressure by relaxing blood vessels. Together, they work to improve heart function and reduce blood pressure. The effects can be noticed relatively quickly, but it may take a few weeks to see the full benefits.

How long does it take for combination of Sacubitril and Valsartan to work?

The combination of Sacubitril and Valsartan, used to treat heart failure, typically starts to work within a few hours of taking the first dose. However, it may take several weeks to experience the full benefits, as the medication helps to improve heart function and reduce symptoms over time. It's important to continue taking the medication as prescribed by your healthcare provider to achieve the best results.

Warnings and Precautions

Are there harms and risks from taking combination of sacubitril and valsartan?

Common side effects of sacubitril and valsartan include dizziness, which is a feeling of lightheadedness, and cough. These occur because the medicines lower blood pressure and affect the respiratory system. Significant adverse effects can include kidney problems and high potassium levels, which can affect heart rhythm. Sacubitril may cause angioedema, which is swelling under the skin, while valsartan can lead to low blood pressure. Monitoring by a healthcare provider is important to manage these effects.

Are there harms and risks from taking combination of Sacubitril and Valsartan?

Yes, there are potential harms and risks associated with taking the combination of Sacubitril and Valsartan. According to the NHS, some common side effects include dizziness, low blood pressure, and high potassium levels in the blood. More serious risks can include kidney problems and angioedema, which is a severe allergic reaction causing swelling under the skin. It's important to monitor for these side effects and consult a healthcare provider if they occur. The NLM also notes that this combination can interact with other medications, so it's crucial to inform your doctor about all the drugs you are taking.

Can I take combination of sacubitril and valsartan with other prescription drugs?

Significant prescription drug interactions with sacubitril and valsartan include other blood pressure medications, which can lead to excessively low blood pressure, and diuretics, which can affect kidney function. ACE inhibitors, which are another type of blood pressure medicine, should not be used with sacubitril and valsartan due to the risk of angioedema. Monitoring involves regular blood pressure checks and kidney function tests. Patients should inform their healthcare provider of all medications to manage these interactions effectively.

Can I take combination of Sacubitril and Valsartan with other prescription drugs?

Sacubitril and Valsartan is a medication used to treat heart failure. It is important to be cautious when taking it with other prescription drugs due to potential interactions. According to the NHS, you should avoid taking it with certain medications like ACE inhibitors, as this can increase the risk of side effects. Additionally, the NLM advises that combining it with drugs that increase potassium levels, such as potassium supplements or certain diuretics, can lead to high potassium levels in the blood, which can be dangerous. Always consult with your healthcare provider or pharmacist before starting any new medication to ensure it is safe to take with Sacubitril and Valsartan. They can provide guidance based on your specific health needs and current medications.

Can I take combination of sacubitril and valsartan if I am pregnant?

Sacubitril and valsartan are not considered safe during pregnancy. They can harm the developing fetus, especially in the second and third trimesters, which are the middle and last stages of pregnancy. Valsartan, in particular, can cause injury or death to the unborn baby. Women who are pregnant or planning to become pregnant should not use this medication. It's important to discuss alternative treatments with a healthcare provider to ensure the safety of both the mother and the baby.

Can I take combination of Sacubitril and Valsartan if I am pregnant?

It is not recommended to take the combination of Sacubitril and Valsartan during pregnancy. According to the NHS, these medications can harm an unborn baby, especially in the second and third trimesters. If you are pregnant or planning to become pregnant, you should discuss alternative treatments with your healthcare provider. Always consult your doctor before starting or stopping any medication during pregnancy.

Can I take combination of sacubitril and valsartan while breastfeeding?

The safety of sacubitril and valsartan during breastfeeding is not well established. It is unclear if these medicines pass into breast milk and what effects they might have on a nursing infant. Due to the potential for serious adverse effects, healthcare providers often recommend alternative treatments for breastfeeding mothers. It's important for mothers to discuss the risks and benefits with their healthcare provider to make an informed decision about using this medication while breastfeeding.

Can I take combination of Sacubitril and Valsartan while breastfeeding?

According to the NHS, it is important to consult with a healthcare professional before taking any medication while breastfeeding. Sacubitril and Valsartan are used to treat heart failure, and their safety during breastfeeding is not well established. The NLM suggests that there is limited information on the effects of these drugs on breastfed infants or on milk production. Therefore, a healthcare provider can help weigh the potential benefits and risks, considering the health of both the mother and the baby.

Who should avoid taking combination of sacubitril and valsartan?

Important warnings for sacubitril and valsartan include the risk of angioedema, which is swelling under the skin, and high potassium levels, which can affect heart rhythm. It's contraindicated in pregnancy due to potential harm to the fetus. People with a history of angioedema or severe kidney problems should avoid this medication. Regular monitoring of blood pressure, kidney function, and potassium levels is essential. Patients should inform their healthcare provider of any other medications or conditions to avoid complications.

Who should avoid taking combination of Sacubitril and Valsartan?

People who should avoid taking the combination of Sacubitril and Valsartan include: 1. **Pregnant Women**: This medication can harm an unborn baby, so it should not be used during pregnancy. 2. **People with Angioedema**: Those who have had angioedema (swelling under the skin) related to previous ACE inhibitor or ARB use should avoid this combination. 3. **Patients with Severe Liver Problems**: Individuals with severe liver impairment should not take this medication. 4. **People with Diabetes Taking Aliskiren**: Those who have diabetes and are taking a medication called Aliskiren should avoid this combination due to potential harmful interactions. 5. **Individuals with Allergies to the Ingredients**: Anyone allergic to Sacubitril, Valsartan, or any other ingredients in the medication should not take it. 6. **Patients with Kidney Problems**: People with certain kidney conditions should consult their doctor before using this medication. It's important to consult a healthcare provider to determine if this medication is safe for you, especially if you have any of the above conditions or concerns.