Lifitegrast
Dry Eye Syndromes
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Lymphocyte Function-Associated Antigen-1 Antagonist
Controlled Drug Substance
No
Summary
Lifitegrast is used to treat dry eye disease, which is a condition where the eyes don't produce enough tears or the right quality of tears. It helps reduce symptoms like dryness, irritation, and discomfort.
Lifitegrast works by blocking a protein called LFA-1, which is involved in the inflammation process in the eyes. By inhibiting this protein, lifitegrast reduces inflammation and helps improve tear production.
Lifitegrast is usually administered as eye drops. The typical dose for adults is one drop in each eye twice daily, approximately 12 hours apart. It's important to follow your doctor's specific dosing instructions.
Common adverse effects of lifitegrast include eye irritation, discomfort, and blurred vision. These effects are usually mild and temporary. If you experience severe or persistent symptoms, contact your doctor.
Lifitegrast may cause temporary blurred vision after application, so avoid driving or operating machinery until your vision clears. It should not be used by individuals who are allergic to it or any of its ingredients.
Indications and Purpose
How does lifitegrast work?
Lifitegrast works by blocking a protein called LFA-1, which is involved in the inflammation process in the eyes. By inhibiting this protein, lifitegrast reduces inflammation and helps improve tear production. Think of it like turning down the heat on a stove to prevent a pot from boiling over. This action helps relieve symptoms of dry eye disease.
Is lifitegrast effective?
Lifitegrast is effective in treating dry eye disease, which is a condition where the eyes don't produce enough tears or the right quality of tears. Clinical studies show that lifitegrast can improve symptoms like eye dryness and discomfort. It works by reducing inflammation in the eyes, helping to relieve symptoms and improve tear production.
What is lifitegrast?
Lifitegrast is a medication used to treat dry eye disease, which is a condition where the eyes don't produce enough tears or the right quality of tears. It belongs to a class of drugs called lymphocyte function-associated antigen-1 (LFA-1) antagonists. Lifitegrast works by reducing inflammation in the eyes, helping to relieve symptoms like dryness and irritation.
Directions for Use
For how long do I take lifitegrast?
Lifitegrast is usually a long-term treatment for managing dry eye disease. You'll typically use it every day as prescribed by your doctor. The duration of use depends on your symptoms and how well you respond to the medication. Always talk with your doctor before changing or stopping your lifitegrast treatment.
How do I dispose of lifitegrast?
To dispose of lifitegrast, follow local guidelines for medication disposal. If available, use a drug take-back program or collection site at a pharmacy. If these options aren't available, you can throw the medication in the trash. Remove it from its original container, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away.
How do I take lifitegrast?
Lifitegrast is usually administered as eye drops. You should use it twice daily, once in the morning and once in the evening. It's important to follow your doctor's instructions on how to use the drops. If you miss a dose, use it as soon as you remember unless it's almost time for your next dose. Then, skip the missed dose and continue your regular schedule. Do not double up on doses.
How long does it take for lifitegrast to start working?
Lifitegrast may start to relieve symptoms of dry eye disease within a few weeks, but it can take up to 12 weeks to achieve its full therapeutic effect. Individual responses can vary, so it's important to use the medication as prescribed and be patient. If you have concerns about how quickly lifitegrast is working, discuss them with your doctor.
How should I store lifitegrast?
Store lifitegrast at room temperature, away from moisture and light. Keep the bottle tightly closed when not in use. Do not store it in the bathroom, where humidity can affect the medication. Always keep lifitegrast out of reach of children to prevent accidental ingestion. Check the expiration date regularly and dispose of any expired medication properly.
What is the usual dose of lifitegrast?
The usual dose of lifitegrast for adults is one drop in each eye twice daily, approximately 12 hours apart. It's important to follow your doctor's specific dosing instructions. If you have any questions about your dose or how to use the medication, consult your healthcare provider for guidance.
Warnings and Precautions
Can I take lifitegrast with other prescription drugs?
Lifitegrast is an eye drop and doesn't have significant drug interactions. However, it's important to inform your doctor about all medications you're taking, including other eye drops. This helps ensure your treatment is safe and effective. If you have concerns about potential interactions, discuss them with your healthcare provider.
Can lifitegrast be taken safely while breastfeeding?
The safety of lifitegrast while breastfeeding is not well-established. It's unclear if the medication passes into breast milk. If you are breastfeeding or planning to breastfeed, discuss the potential risks and benefits with your doctor. They can help determine the best treatment plan for you and your baby.
Can lifitegrast be taken safely while pregnant?
The safety of lifitegrast during pregnancy is not well-established. There is limited information on its use in pregnant women. If you are pregnant or planning to become pregnant, talk with your doctor about the potential risks and benefits of using lifitegrast. Your doctor can help determine the best treatment plan for your situation.
Does lifitegrast have adverse effects?
Adverse effects are unwanted reactions to a medication. With lifitegrast, common adverse effects include eye irritation, discomfort, or blurred vision. These effects are usually mild and temporary. If you experience severe or persistent symptoms, contact your doctor. Always inform your healthcare provider about any new or worsening symptoms while using lifitegrast.
Does lifitegrast have any safety warnings?
Lifitegrast has some safety warnings. It may cause temporary blurred vision after application, so avoid driving or operating machinery until your vision clears. If you experience eye discomfort, redness, or other symptoms that persist, contact your doctor. It's important to follow your doctor's instructions and not to use the medication more frequently than prescribed.
Is it safe to drink alcohol while taking lifitegrast?
There are no known interactions between lifitegrast and alcohol. However, it's always a good idea to consume alcohol in moderation and discuss any concerns with your doctor. If you notice any unusual symptoms while using lifitegrast and consuming alcohol, talk with your healthcare provider for personalized advice.
Is it safe to exercise while taking lifitegrast?
Yes, it's safe to exercise while using lifitegrast. This medication is an eye drop and doesn't typically affect your ability to exercise. If you experience any unusual symptoms during physical activity, such as eye discomfort, talk with your doctor. They can provide guidance on managing your symptoms while maintaining an active lifestyle.
Is it safe to stop lifitegrast?
Lifitegrast is typically used for long-term management of dry eye disease. Stopping it suddenly may lead to a return of symptoms. If you wish to stop using lifitegrast, consult your doctor first. They can guide you on how to safely discontinue the medication or suggest alternative treatments to manage your condition.
Is lifitegrast addictive?
Lifitegrast is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop using it. Lifitegrast works locally in the eyes and doesn't affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, you can feel confident that lifitegrast doesn't carry this risk.
Is lifitegrast safe for the elderly?
Lifitegrast is generally safe for elderly patients, but they may be more sensitive to its effects. It's important for older adults to follow their doctor's instructions and report any unusual symptoms. Regular check-ups can help monitor the medication's effectiveness and adjust the treatment plan as needed for safety.
What are the most common side effects of lifitegrast?
Side effects are unwanted reactions that can happen when taking a medication. With lifitegrast, common side effects include eye irritation, discomfort, and blurred vision. These effects are usually mild and temporary. If you notice new symptoms after starting lifitegrast, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking lifitegrast?
Lifitegrast should not be used by individuals who are allergic to it or any of its ingredients. If you experience an allergic reaction, which may include symptoms like rash, itching, or swelling, seek medical help immediately. Always inform your doctor about any allergies or medical conditions before starting lifitegrast.
