Glasdegib
Acute Myeloid Leukemia
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Hedgehog Pathway Inhibitor
Controlled Drug Substance
No
Summary
Glasdegib is used to treat certain types of blood cancers, such as acute myeloid leukemia, which is a cancer of the blood and bone marrow. It is often combined with other treatments to improve patient outcomes.
Glasdegib works by inhibiting the hedgehog signaling pathway, which is a communication line that cancer cells use to grow and survive. By blocking this pathway, glasdegib helps slow down or stop the growth of cancer cells.
The usual starting dose of glasdegib for adults is 100 mg taken once daily. It can be taken with or without food, but the tablet should not be crushed or chewed. Always follow your doctor's specific dosing instructions.
Common side effects of glasdegib include nausea, fatigue, and decreased appetite. These effects vary among individuals and are usually mild. If you experience any new or worsening symptoms, contact your doctor.
Glasdegib can cause serious side effects like bone marrow suppression, which affects blood cell production and can lead to infections or bleeding. Regular blood tests are needed. It's not recommended for pregnant or breastfeeding women due to potential risks to the baby.
Indications and Purpose
How does glasdegib work?
Glasdegib works by inhibiting the hedgehog signaling pathway, which is involved in the growth and survival of cancer cells. Think of it like blocking a communication line that cancer cells use to thrive. By disrupting this pathway, glasdegib helps slow down or stop the growth of cancer cells, making it effective in treating certain blood cancers.
Is glasdegib effective?
Glasdegib is effective in treating certain types of blood cancers, like acute myeloid leukemia, which is a cancer of the blood and bone marrow. It works by inhibiting a pathway that cancer cells use to grow. Clinical studies show glasdegib, when combined with other treatments, improves survival rates in patients with this condition. Always follow your doctor's treatment plan for the best outcomes.
What is glasdegib?
Glasdegib is a medication used to treat certain types of blood cancers, like acute myeloid leukemia, which is a cancer of the blood and bone marrow. It belongs to a class of drugs called hedgehog pathway inhibitors, which work by blocking signals that cancer cells use to grow. Glasdegib is often used in combination with other treatments to improve outcomes in patients with these conditions.
Directions for Use
For how long do I take glasdegib?
Glasdegib is usually a long-term medication for managing certain blood cancers. The duration of use depends on your response to treatment and your doctor's recommendations. Stopping glasdegib without medical advice could cause your condition to worsen. Always talk with your doctor before changing or stopping your glasdegib treatment.
How do I dispose of glasdegib?
Dispose of unused glasdegib by taking it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take glasdegib?
Take glasdegib as prescribed by your doctor, usually once daily. You can take it with or without food. Do not crush or chew the tablet. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Avoid taking two doses at once. Always follow your doctor's specific instructions.
How long does it take for glasdegib to start working?
Glasdegib starts working in your body shortly after you take it, but the full therapeutic effects may take weeks to become noticeable. The time it takes to see results can vary based on individual factors like your overall health and the specific condition being treated. Regular check-ups and tests with your doctor will help monitor your progress and adjust your treatment as needed.
How should I store glasdegib?
Store glasdegib at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. If your pills came in packaging that isn't child-resistant, transfer them to a container that children can't easily open. Always store glasdegib out of children's reach to prevent accidental swallowing.
What is the usual dose of glasdegib?
The usual starting dose of glasdegib for adults is 100 mg once daily. Your doctor will provide specific dosing instructions based on your health needs. It's important to follow your doctor's guidance and not adjust the dose on your own. If you have any concerns about your dosage, discuss them with your healthcare provider.
Warnings and Precautions
Can glasdegib be taken safely while breastfeeding?
Glasdegib is not recommended while breastfeeding. We don't have much information about whether it passes into human breast milk. However, it may pose risks to a baby's development. If you're taking glasdegib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can glasdegib be taken safely while pregnant?
Glasdegib is not recommended during pregnancy due to potential harm to the unborn baby. Animal studies show it can cause birth defects. We don't have much information about glasdegib use in pregnant women. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options. Your doctor can help create a plan that protects both you and your baby.
Can I take glasdegib with other prescription drugs?
Glasdegib can interact with certain medications, increasing the risk of side effects or reducing effectiveness. For example, it may interact with strong CYP3A inhibitors, which can increase glasdegib levels in the blood. Always inform your doctor about all medications you're taking to avoid potential interactions. Your doctor can adjust your treatment plan to ensure safety and effectiveness.
Does glasdegib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of glasdegib include nausea, fatigue, and decreased appetite. Serious side effects can include bone marrow suppression, leading to infections or bleeding. If you notice any new or worsening symptoms, contact your doctor. Regular monitoring and communication with your healthcare provider can help manage any adverse effects.
Does glasdegib have any safety warnings?
Yes, glasdegib has important safety warnings. It can cause serious side effects, including bone marrow suppression, which affects blood cell production. This can lead to infections, anemia, or bleeding. Regular blood tests are needed to monitor your blood cell levels. If you experience unusual bruising, bleeding, or signs of infection, contact your doctor immediately. Always follow your doctor's instructions and report any new or worsening symptoms.
Is glasdegib addictive?
Glasdegib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Glasdegib works by affecting cancer cells, not brain chemistry, so it doesn't lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, glasdegib doesn't carry this risk.
Is glasdegib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of glasdegib, such as bone marrow suppression, which affects blood cell production. This can lead to infections or bleeding. Regular monitoring and communication with your healthcare provider are important to manage any risks. Always follow your doctor's instructions and report any new or worsening symptoms.
Is it safe to drink alcohol while taking glasdegib?
It's best to avoid alcohol while taking glasdegib. Alcohol can increase the risk of side effects like nausea and dizziness. It may also interfere with your treatment. If you choose to drink occasionally, limit your alcohol intake and watch for any warning signs. Talk with your doctor about alcohol use while taking glasdegib for personalized advice.
Is it safe to exercise while taking glasdegib?
You can exercise while taking glasdegib, but be cautious. This medication can cause fatigue and dizziness, which might affect your exercise capacity. To exercise safely, listen to your body and avoid strenuous activities if you feel unwell. Drink plenty of water before, during, and after physical activity. If you notice any unusual symptoms, slow down or stop exercising and rest.
Is it safe to stop glasdegib?
Stopping glasdegib suddenly can affect your treatment. It's used for long-term management of certain cancers. Stopping without medical advice could worsen your condition. Always talk with your doctor before stopping glasdegib. They might suggest a gradual reduction or alternative treatment to keep your condition under control.
What are the most common side effects of glasdegib?
Side effects are unwanted reactions to a medication. Common side effects of glasdegib include nausea, fatigue, and decreased appetite. These effects vary from person to person. If you notice new symptoms after starting glasdegib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking glasdegib?
Don't take glasdegib if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Glasdegib is not recommended for pregnant women due to potential harm to the unborn baby. Breastfeeding mothers should avoid it as it may pass into breast milk. Always consult your doctor about these concerns.
