Ganaxolone
Seizures
.svg)
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Neuroactive Steroid Gamma-Aminobutyric Acid A Receptor Positive Modulator
Controlled Drug Substance
YES
Summary
Ganaxolone is used to treat certain types of seizures, which are sudden, uncontrolled electrical disturbances in the brain. It helps reduce the frequency and severity of these episodes, often as an additional therapy alongside other seizure medications.
Ganaxolone works by modulating GABA receptors, which are proteins in the brain that help control electrical activity. This action stabilizes brain function, reducing seizures and improving overall brain health.
The typical starting dose for adults is 900 mg per day, divided into three doses of 300 mg each. Ganaxolone is taken orally, usually with food, to help with absorption and reduce stomach upset.
Common side effects include dizziness, drowsiness, and fatigue, which refer to feeling tired or lacking energy. These effects are generally mild and temporary, but if they persist, consulting a doctor is advised.
Ganaxolone may cause drowsiness, so avoid driving or operating heavy machinery until you know how it affects you. Alcohol can increase drowsiness, so it's best to avoid it. If you have liver problems, consult your doctor before use.
Indications and Purpose
How does ganaxolone work?
Ganaxolone works by modulating GABA receptors in the brain, which helps stabilize electrical activity. Think of it like adjusting the volume on a radio to reduce static. This action helps reduce seizures and improve brain function. Ganaxolone is effective in treating certain types of seizures.
Is ganaxolone effective?
Ganaxolone is effective in treating certain types of seizures. It works by modulating GABA receptors in the brain, which helps stabilize electrical activity. Clinical studies show ganaxolone can reduce seizure frequency in patients with epilepsy. Always follow your doctor's advice to achieve the best results.
What is ganaxolone?
Ganaxolone is a medication used to treat certain types of seizures. It belongs to a class of drugs called neuroactive steroids, which work by modulating GABA receptors in the brain. This helps stabilize electrical activity and reduce seizures. Ganaxolone is used as a complementary addition to other therapies for seizure management.
Directions for Use
For how long do I take ganaxolone?
Ganaxolone is usually used for short-term treatment of seizures. The duration of use depends on your condition and how you respond to the medication. Your doctor will guide you on how long to take ganaxolone. Always follow your doctor's advice and don't stop taking it without consulting them.
How do I dispose of ganaxolone?
Dispose of unused ganaxolone by taking it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away in the trash.
How do I take ganaxolone?
Ganaxolone is usually taken three times a day with food. It's important to follow your doctor's instructions on the exact dosage and timing. Do not crush or chew the capsules. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Never take two doses at once.
How long does it take for ganaxolone to start working?
Ganaxolone begins working shortly after you take it, but the full therapeutic effect may take several weeks. The time it takes to notice improvements can vary based on individual factors like your condition and overall health. Always take ganaxolone as prescribed and talk with your doctor if you have concerns about its effectiveness.
How should I store ganaxolone?
Store ganaxolone at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. Always keep ganaxolone out of children's reach to prevent accidental ingestion. Check the expiration date regularly and dispose of any unused or expired medication properly.
What is the usual dose of ganaxolone?
The usual starting dose of ganaxolone for adults is 900 mg per day, divided into three doses of 300 mg each. Your doctor may adjust the dose based on your response and any side effects. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can ganaxolone be taken safely while breastfeeding?
Ganaxolone's safety during breastfeeding is not well-established. It's unclear if it passes into breast milk or affects milk production. If you're breastfeeding or planning to, talk with your doctor about safer medication options. Your doctor can help you make informed decisions about your treatment.
Can ganaxolone be taken safely while pregnant?
The safety of ganaxolone during pregnancy is not well-established. Animal studies suggest potential risks, but human data is limited. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take ganaxolone with other prescription drugs?
Ganaxolone may interact with other medications that cause drowsiness, such as sedatives or alcohol. These interactions can increase drowsiness or dizziness. Always inform your doctor about all the medications you're taking to avoid potential interactions. Your doctor can help manage any interactions and adjust your treatment plan as needed.
Does ganaxolone have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of ganaxolone include dizziness, drowsiness, and fatigue. These effects are usually mild. Serious side effects are rare but can include allergic reactions. If you experience any severe or persistent symptoms, contact your doctor immediately.
Does ganaxolone have any safety warnings?
Ganaxolone has safety warnings you should be aware of. It may cause drowsiness, so avoid driving or operating heavy machinery until you know how it affects you. Alcohol can increase drowsiness, so it's best to avoid it. If you experience severe side effects like difficulty breathing or swelling, seek medical help immediately. Always follow your doctor's advice and report any unusual symptoms.
Is ganaxolone addictive?
Ganaxolone is not considered addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. If you have concerns about medication dependence, you can feel confident that ganaxolone doesn't carry this risk while managing your health condition.
Is ganaxolone safe for the elderly?
Elderly individuals may be more sensitive to the side effects of ganaxolone, such as dizziness or drowsiness. These effects can increase the risk of falls. It's important for elderly patients to be closely monitored by their doctor while taking ganaxolone. Dose adjustments may be necessary to ensure safety.
Is it safe to drink alcohol while taking ganaxolone?
It's best to avoid alcohol while taking ganaxolone. Alcohol can increase drowsiness and dizziness, which are side effects of ganaxolone. If you choose to drink, limit your intake and watch for warning signs like increased drowsiness or dizziness. Talk with your doctor about alcohol use while taking ganaxolone.
Is it safe to exercise while taking ganaxolone?
You can exercise while taking ganaxolone, but be cautious. This medication can cause dizziness or drowsiness, which might affect your balance and coordination. To exercise safely, start with light activities and see how your body responds. If you feel dizzy or lightheaded, stop and rest. Always talk with your doctor about your exercise plans.
Is it safe to stop ganaxolone?
Ganaxolone is usually used for short-term treatment of seizures. Stopping it suddenly can cause your condition to worsen. Always talk with your doctor before stopping ganaxolone. They might suggest gradually reducing your dose to prevent withdrawal symptoms and keep your condition under control.
What are the most common side effects of ganaxolone?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of ganaxolone include dizziness, drowsiness, and fatigue. These effects vary from person to person. If you notice new symptoms after starting ganaxolone, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking ganaxolone?
Do not take ganaxolone if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Caution is needed if you have liver problems, as ganaxolone is processed by the liver. Always consult your doctor about any concerns before starting ganaxolone.
