Eplerenone
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Aldosterone Antagonist
Controlled Drug Substance
NO
Eplerenone
Summary
Eplerenone is used to treat high blood pressure and conditions like heart failure after a heart attack.
Eplerenone works by blocking aldosterone, a hormone that causes the body to retain sodium and water. This reduces sodium and water retention, helping to decrease blood pressure and strain on the heart.
For high blood pressure, the typical adult dose is 50 mg once daily. In heart failure, it's often started at 25 mg daily, then increased to 50 mg daily depending on tolerance and response.
Common side effects include increased potassium levels, dizziness, and fatigue. Rarely, it may cause kidney problems or breast enlargement in men.
Avoid Eplerenone if you have high potassium levels, severe kidney problems, or are taking strong CYP3A4 inhibitors like ketoconazole. It is also not known if Eplerenone passes into breast milk, so consult your doctor if you are breastfeeding. It should only be used during pregnancy if clearly needed.
Indications and Purpose
How does Eplerenone work?
Eplerenone blocks aldosterone receptors in the kidneys, reducing sodium and water retention while maintaining potassium levels. This helps decrease blood pressure and strain on the heart.
Is Eplerenone effective?
Yes, studies show Eplerenone significantly reduces blood pressure and prevents heart failure complications, particularly when used as prescribed and in combination with other treatments.
What is Eplerenone?
Eplerenone is a potassium-sparing diuretic (water pill) used to lower blood pressure and treat conditions like heart failure after a heart attack. It works by blocking aldosterone, a hormone that causes the body to retain sodium and water.
Directions for Use
For how long do I take Eplerenone?
It is usually a long-term medication for managing chronic conditions like high blood pressure or heart failure. Follow your doctor’s advice on the duration of treatment.
How do I take Eplerenone?
Take Eplerenone with or without food, at the same time each day. Avoid using potassium supplements or salt substitutes unless your doctor advises it, as it may raise potassium levels.
How long does it take for Eplerenone to start working?
Its effects on blood pressure can be observed within 2 to 4 weeks of starting treatment, while heart failure symptoms may improve in several days to weeks.
How should I store Eplerenone?
Store Eplerenone at room temperature, away from moisture and heat. Keep it in a secure place, out of reach of children and pets.
What is the usual dose of Eplerenone?
For hypertension, the typical adult dose is 50 mg once daily. In heart failure, it’s often started at 25 mg daily, then increased to 50 mg daily, depending on tolerance and response.
Warnings and Precautions
Can Eplerenone be taken safely while breastfeeding?
It is unknown if Eplerenone passes into breast milk. Consult your doctor before using it while breastfeeding to evaluate risks to the baby.
Can Eplerenone be taken safely while pregnant?
There’s limited data on its safety during pregnancy. It should only be used if clearly needed and prescribed by a doctor after weighing the risks and benefits.
Can I take Eplerenone with other prescription drugs?
It interacts with drugs like ACE inhibitors, ARBs, NSAIDs, and strong CYP3A4 inhibitors, increasing the risk of high potassium. Inform your doctor about all medications you take.
Is Eplerenone safe for the elderly?
It is generally safe, but elderly patients should be closely monitored, especially for changes in kidney function and potassium levels, as they may be more sensitive to the drug's effects.
Is it safe to drink alcohol while taking Eplerenone?
Alcohol may enhance dizziness or lower blood pressure too much when combined with Eplerenone. It’s best to limit alcohol consumption or avoid it altogether unless your doctor advises otherwise.
Is it safe to exercise while taking Eplerenone?
Yes, but avoid intense workouts if you feel dizzy or weak due to low blood pressure. Consult your doctor about a suitable exercise routine tailored to your condition.
Who should avoid taking Eplerenone?
Avoid it if you have high potassium levels, severe kidney problems, or are taking strong CYP3A4 inhibitors (e.g., ketoconazole). Always consult your doctor for specific contraindications.
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