Entrectinib
Non-Small-Cell Lung Carcinoma
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
entrectinib
Summary
Entrectinib is used to treat certain types of cancer, including non-small cell lung cancer and solid tumors with specific genetic markers, which are unique features in the DNA of cancer cells.
Entrectinib works by blocking proteins called tyrosine kinases, which help cancer cells grow and spread. By inhibiting these proteins, it can slow or stop the growth of cancer cells, helping to shrink tumors.
The usual starting dose of Entrectinib for adults is 600 mg once daily. It is taken orally, which means by mouth, and can be taken with or without food. Always follow your doctor's specific dosing instructions.
Common side effects of Entrectinib include fatigue, which is extreme tiredness, dizziness, and nausea, which is a feeling of sickness with an inclination to vomit. These effects can vary from person to person.
Entrectinib can cause heart problems, including heart failure, which is when the heart can't pump blood effectively, and liver problems, which can lead to liver damage. It is not recommended during pregnancy or breastfeeding.
Indications and Purpose
How does Entrectinib work?
Entrectinib works by blocking proteins called tyrosine kinases, which help cancer cells grow and spread. By inhibiting these proteins, Entrectinib can slow or stop the growth of cancer cells. This action helps shrink tumors and improve symptoms in patients with certain types of cancer.
Is Entrectinib effective?
Entrectinib is effective for treating certain types of cancer, including non-small cell lung cancer and solid tumors with specific genetic markers. Clinical studies show that Entrectinib can shrink tumors and improve survival rates in patients with these conditions. Your doctor will monitor your response to the medication to ensure it's working effectively for you.
What is Entrectinib?
Entrectinib is a medication used to treat certain types of cancer, including non-small cell lung cancer and solid tumors with specific genetic markers. It works by blocking proteins that help cancer cells grow. Entrectinib is part of a class of drugs called tyrosine kinase inhibitors, which target specific enzymes in cancer cells.
Directions for Use
For how long do I take Entrectinib?
Entrectinib is usually taken long-term for managing cancer. The duration depends on your response to treatment and any side effects you experience. Your doctor will guide you on how long to continue taking Entrectinib based on your specific health needs. Always talk with your doctor before changing or stopping your Entrectinib treatment.
How do I dispose of Entrectinib?
Bring unused Entrectinib to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Entrectinib?
Take Entrectinib once daily, with or without food. Swallow the capsule whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for Entrectinib to start working?
Entrectinib begins working in your body shortly after you take it, but the time to see noticeable effects can vary. Some patients may notice improvements in symptoms within a few weeks, while others may take longer. Your doctor will monitor your progress to determine how well the medication is working for you.
How should I store Entrectinib?
Store Entrectinib at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. Always store Entrectinib out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Entrectinib?
The usual starting dose of Entrectinib for adults is 600 mg once daily. Your doctor may adjust your dose based on your response and any side effects. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can Entrectinib be taken safely while breastfeeding?
Entrectinib is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. If you're taking Entrectinib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Entrectinib be taken safely while pregnant?
Entrectinib isn't recommended during pregnancy. It may harm an unborn baby. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take Entrectinib with other prescription drugs?
Entrectinib can interact with certain medications, increasing the risk of side effects or reducing effectiveness. Major interactions include drugs that affect liver enzymes, which can alter Entrectinib levels in your body. Always inform your doctor about all medications you take to avoid potential interactions.
Does Entrectinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Entrectinib include fatigue, dizziness, and nausea. Serious effects can include heart problems and liver damage. If you notice any new or worsening symptoms, contact your doctor immediately. They can help determine if these symptoms are related to Entrectinib and suggest appropriate actions.
Does Entrectinib have any safety warnings?
Entrectinib has important safety warnings. It can cause heart problems, including heart failure, which is when your heart can't pump blood effectively. It may also cause liver problems, which can lead to liver damage. If you experience symptoms like shortness of breath, swelling, or yellowing of the skin, seek medical help. Always follow your doctor's advice and report any new symptoms.
Is Entrectinib addictive?
Entrectinib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. If you have concerns about medication dependence, you can feel confident that Entrectinib doesn't carry this risk while managing your health condition.
Is Entrectinib safe for the elderly?
Elderly patients may be more vulnerable to side effects of Entrectinib, such as heart and liver problems. It's important for older adults to be closely monitored by their doctor while taking this medication. Your doctor will consider your overall health and any other medications you take to ensure Entrectinib is safe for you.
Is it safe to drink alcohol while taking Entrectinib?
It's best to avoid alcohol while taking Entrectinib. Alcohol can increase the risk of liver damage, which is a serious side effect of Entrectinib. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like nausea or yellowing of the skin. Talk with your doctor about alcohol use while taking Entrectinib.
Is it safe to exercise while taking Entrectinib?
You can exercise while taking Entrectinib, but keep a few things in mind. This medication can cause fatigue and dizziness, which might affect your exercise capacity. To exercise safely, listen to your body and rest if you feel tired or dizzy. Most people can maintain their regular exercise routine while taking Entrectinib, but check with your doctor if you have concerns.
Is it safe to stop Entrectinib?
Stopping Entrectinib suddenly can cause your condition to worsen. Always talk with your doctor before stopping the medication. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
What are the most common side effects of Entrectinib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Entrectinib include fatigue, dizziness, and nausea. These effects vary from person to person. If you notice new symptoms after starting Entrectinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Entrectinib?
Don't take Entrectinib if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Entrectinib shouldn't be used by people with severe liver problems, as it might worsen liver function. Always consult your doctor about these concerns.
