Edoxaban
Pulmonary Embolism, Venous Thrombosis
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
No
Pharmaceutical Class
Factor Xa Inhibitor
Controlled Drug Substance
No
Edoxaban
Summary
Edoxaban is used to prevent strokes and blood clots in patients with a condition called nonvalvular atrial fibrillation. It's also used to treat deep vein thrombosis, which is a blood clot in the leg, and pulmonary embolism, a blood clot in the lung.
Edoxaban works by inhibiting a key enzyme in the blood clotting process called factor Xa. By blocking this enzyme, Edoxaban reduces the formation of blood clots, helping to prevent strokes and other clot-related conditions.
For adults, the usual dose of Edoxaban is 60 mg taken once daily. It's taken orally, meaning you swallow it. The safety and effectiveness of Edoxaban for children have not been established.
Common side effects of Edoxaban include bleeding, rash, and abnormal liver function tests. Serious side effects can include major bleeding events, such as bleeding in the brain.
Edoxaban carries a risk of bleeding, which can be serious or fatal. If you stop taking Edoxaban prematurely, it can increase your risk of stroke. It's not recommended for patients with active bleeding, severe liver problems, mechanical heart valves, or moderate to severe narrowing of the heart's mitral valve.
Indications and Purpose
How does Edoxaban work?
Edoxaban works by inhibiting a protein called factor Xa, which plays a key role in the blood clotting process. By blocking this protein, Edoxaban helps prevent the formation of blood clots. Think of it like turning off a switch that triggers clotting. This action makes Edoxaban effective in reducing the risk of stroke and blood clots in conditions like atrial fibrillation.
Is Edoxaban effective?
Edoxaban is effective in preventing blood clots in conditions like atrial fibrillation and after certain surgeries. Clinical studies show it reduces the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation. It also helps prevent and treat deep vein thrombosis and pulmonary embolism. Always follow your doctor's instructions to ensure the best outcomes.
What is Edoxaban?
Edoxaban is an anticoagulant, which is a type of medication that helps prevent blood clots. It works by inhibiting a specific protein involved in blood clotting. Edoxaban is primarily used to reduce the risk of stroke and blood clots in people with atrial fibrillation, which is an irregular heartbeat. It's also used to treat and prevent deep vein thrombosis and pulmonary embolism, which are types of blood clots.
Directions for Use
For how long do I take Edoxaban?
Edoxaban is usually a long-term medication for preventing blood clots in conditions like atrial fibrillation. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your Edoxaban treatment.
How do I dispose of Edoxaban?
To dispose of Edoxaban, take it to a drug take-back program or collection site at a pharmacy or hospital. If that's not possible, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away. This helps prevent harm to people and the environment.
How do I take Edoxaban?
Edoxaban is usually taken once daily, with or without food. It's important to take it at the same time each day. Do not crush or chew the tablets. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Never take two doses at once. Always follow your doctor's specific instructions regarding diet and fluid intake while on this medication.
How long does it take for Edoxaban to start working?
Edoxaban begins working in your body shortly after you take it, reaching its highest levels in your blood within a few hours. However, you may not notice all the benefits right away. The full therapeutic effect, such as preventing blood clots, may take some time to become apparent. Always take Edoxaban exactly as prescribed for the best results.
How should I store Edoxaban?
Store Edoxaban at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Don't store it in humid places like bathrooms. Always keep Edoxaban out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Edoxaban?
The usual starting dose of Edoxaban for adults is 60 mg once daily. However, the dose may be adjusted based on your kidney function or if you are taking certain other medications. For some patients, a lower dose of 30 mg daily may be recommended. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can Edoxaban be taken safely while breastfeeding?
The safety of Edoxaban while breastfeeding is not well-established. It's unclear if the medication passes into breast milk. If you're breastfeeding or planning to breastfeed, talk with your doctor about safer medication options. Your doctor can help you choose a treatment that allows you to nurse your baby safely.
Can Edoxaban be taken safely while pregnant?
The safety of Edoxaban during pregnancy is not well-established. It's generally not recommended due to potential risks to the unborn baby. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take Edoxaban with other prescription drugs?
Edoxaban can interact with other medications that affect bleeding, such as aspirin, NSAIDs, and other anticoagulants. These interactions can increase the risk of bleeding. Always inform your doctor about all the medications you take to prevent interactions and ensure your treatment is safe and effective.
Does Edoxaban have adverse effects?
Adverse effects are unwanted reactions to a medication. With Edoxaban, common adverse effects include bleeding and bruising. Serious side effects can include severe bleeding, which requires immediate medical attention. If you notice any unusual symptoms or side effects, contact your doctor promptly. Regular monitoring by your healthcare provider can help manage any adverse effects.
Does Edoxaban have any safety warnings?
Yes, Edoxaban has important safety warnings. It can increase the risk of bleeding, which can be serious or even life-threatening. If you experience unusual bleeding or bruising, contact your doctor immediately. Edoxaban should not be stopped suddenly without consulting your doctor, as this can increase the risk of blood clots. Always follow your doctor's instructions and report any side effects or concerns.
Is Edoxaban addictive?
Edoxaban is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Edoxaban works by affecting blood clotting and doesn't impact brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Edoxaban safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Edoxaban, such as bleeding. However, it can be safely used with careful monitoring. Your doctor may adjust the dose based on kidney function and other health factors. Regular check-ups are important to ensure the medication is working effectively and safely.
Is it safe to drink alcohol while taking Edoxaban?
It's best to avoid alcohol while taking Edoxaban. Alcohol can increase the risk of bleeding, which is a serious side effect of this medication. If you choose to drink occasionally, limit your alcohol intake and watch for signs of bleeding, such as unusual bruising or bleeding gums. Talk with your doctor about alcohol use while taking Edoxaban.
Is it safe to exercise while taking Edoxaban?
You can exercise while taking Edoxaban, but be cautious. This medication increases the risk of bleeding, so avoid activities with a high risk of injury. If you notice unusual bruising or bleeding, stop exercising and contact your doctor. Most people can maintain their regular exercise routine, but check with your doctor if you have concerns.
Is it safe to stop Edoxaban?
Stopping Edoxaban suddenly can increase the risk of blood clots, which can be dangerous. Always talk with your doctor before stopping Edoxaban. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
What are the most common side effects of Edoxaban?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Edoxaban include bleeding and bruising. These effects vary from person to person. If you notice new symptoms after starting Edoxaban, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Edoxaban?
Don't take Edoxaban if you have active bleeding or a known allergy to it. It's not recommended for people with severe liver disease or those with artificial heart valves. Use caution if you have kidney problems or are taking other medications that affect bleeding. Always consult your doctor about your medical history before starting Edoxaban.
