Amlodipine + Indapamide

Find more information about this combination medication at the webpages for indapamide and amlodipine

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Brand Name

Natrilam 2.5mg Tablet SR 10s , Natrilam 5 Tablet SR 10s ... show more

Approved Treatment Indication:

Hypertension, Variant Angina Pectoris ... show more

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This medicine contains a combination of 2 drugs amlodipine and indapamide.
amlodipine and indapamide are both used to treat the same disease or symptom but work in different ways in the body.
Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.

Summary

What conditions are Amlodipine and Indapamide used for?
Amlodipine and Indapamide are primarily used to treat high blood pressure, also known as hypertension. Additionally, Amlodipine can be used to treat chest pain, known as angina, and other conditions caused by coronary artery disease. Indapamide may be used for fluid retention, or edema, associated with heart failure.
How do Amlodipine and Indapamide work in the body?
Amlodipine is a calcium channel blocker. It works by relaxing blood vessels, making it easier for the heart to pump blood. Indapamide is a diuretic, which means it helps the body get rid of excess salt and water, reducing blood volume and pressure. They work in different ways but both aim to lower blood pressure.
What are the usual dosages and routes of administration of Amlodipine and Indapamide?
The usual adult daily dose for Amlodipine is 5 mg to 10 mg once daily, and for Indapamide, it's 1.25 mg to 2.5 mg once daily. Both medications are taken orally, often together to enhance blood pressure control. The exact dosage may vary based on individual health conditions and the doctor's recommendations.
What are the most commonly observed adverse effects of Amlodipine and Indapamide?
Common side effects of Amlodipine include swelling of the ankles or feet, dizziness, and flushing. Indapamide may cause side effects like low potassium levels, dizziness, and fatigue. Both medications can cause dizziness, especially when standing up quickly due to their blood pressure-lowering effects.
What are the important safety warnings and contraindications of Amlodipine and Indapamide?
Amlodipine should be used with caution in patients with severe heart conditions as it can affect heart rate and rhythm. Indapamide is not recommended for patients with severe kidney disease or electrolyte imbalances. Both medications should be used cautiously in patients with liver disease. Patients should avoid abruptly stopping these medications as it can lead to a sudden increase in blood pressure.

Government Approvals

None

WHO Essential Medicine

Known Teratogen

Pharmaceutical Class

Calcium Channel Blocker and Dihydropyridine Calcium Channel Blocker and Thiazide-like Diuretic

Controlled Drug Substance

Summary

What conditions are Amlodipine and Indapamide used for?
Amlodipine and Indapamide are primarily used to treat high blood pressure, also known as hypertension. Additionally, Amlodipine can be used to treat chest pain, known as angina, and other conditions caused by coronary artery disease. Indapamide may be used for fluid retention, or edema, associated with heart failure.
How do Amlodipine and Indapamide work in the body?
Amlodipine is a calcium channel blocker. It works by relaxing blood vessels, making it easier for the heart to pump blood. Indapamide is a diuretic, which means it helps the body get rid of excess salt and water, reducing blood volume and pressure. They work in different ways but both aim to lower blood pressure.
What are the usual dosages and routes of administration of Amlodipine and Indapamide?
The usual adult daily dose for Amlodipine is 5 mg to 10 mg once daily, and for Indapamide, it's 1.25 mg to 2.5 mg once daily. Both medications are taken orally, often together to enhance blood pressure control. The exact dosage may vary based on individual health conditions and the doctor's recommendations.
What are the most commonly observed adverse effects of Amlodipine and Indapamide?
Common side effects of Amlodipine include swelling of the ankles or feet, dizziness, and flushing. Indapamide may cause side effects like low potassium levels, dizziness, and fatigue. Both medications can cause dizziness, especially when standing up quickly due to their blood pressure-lowering effects.
What are the important safety warnings and contraindications of Amlodipine and Indapamide?
Amlodipine should be used with caution in patients with severe heart conditions as it can affect heart rate and rhythm. Indapamide is not recommended for patients with severe kidney disease or electrolyte imbalances. Both medications should be used cautiously in patients with liver disease. Patients should avoid abruptly stopping these medications as it can lead to a sudden increase in blood pressure.

Indications and Purpose

How does combination of Amlodipine and Indapamide work?

Amlodipine works by blocking calcium channels in the blood vessel walls, leading to relaxation and dilation of the vessels, which lowers blood pressure. Indapamide acts as a diuretic, increasing the excretion of sodium and water through the kidneys, which reduces blood volume and pressure. Both medications aim to lower blood pressure but do so through different mechanisms, making them complementary in treating hypertension.

How effective is combination of Amlodipine and Indapamide?

Clinical studies have demonstrated that Amlodipine effectively lowers blood pressure and reduces the risk of cardiovascular events such as heart attacks and strokes. Indapamide has also been shown to effectively reduce blood pressure and improve outcomes in patients with hypertension. When used together, these medications provide a complementary approach to blood pressure management, with Amlodipine relaxing blood vessels and Indapamide reducing blood volume. The combination has been proven to be effective in various patient populations, including those with resistant hypertension.

Directions for Use

What is the usual dose of combination of Amlodipine and Indapamide?

The usual adult daily dose for Amlodipine is 5 mg to 10 mg once daily, depending on the patient's response and tolerance. For Indapamide, the typical dose is 1.25 mg to 2.5 mg once daily. Both medications are taken orally and are often prescribed together to enhance blood pressure control. The exact dosage may vary based on individual health conditions and the doctor's recommendations.

How does one take combination of Amlodipine and Indapamide?

Amlodipine and Indapamide can be taken with or without food, but it is important to take them at the same time each day to maintain consistent blood levels. Patients should avoid excessive consumption of alcohol, as it can enhance the blood pressure-lowering effects and increase the risk of side effects. Additionally, those taking Indapamide should monitor their salt intake, as it can affect the drug's efficacy. It's crucial to follow the healthcare provider's instructions regarding diet and lifestyle changes.

For how long is combination of Amlodipine and Indapamide taken?

Amlodipine and Indapamide are typically used as long-term treatments for managing high blood pressure. Patients may need to take these medications indefinitely to maintain blood pressure control and prevent complications. Regular monitoring by a healthcare provider is essential to adjust dosages as needed and to ensure the medications continue to be effective and safe.

How long does it take for combination of Amlodipine and Indapamide to work?

Amlodipine typically starts working within 24 to 48 hours, but it may take a week or two to see the full effect on blood pressure. Indapamide, on the other hand, can start to reduce blood pressure within a few hours of the first dose, but like Amlodipine, it may take several weeks to achieve the full therapeutic effect. Both medicines work to lower blood pressure, but they do so through different mechanisms. Amlodipine is a calcium channel blocker that relaxes blood vessels, while Indapamide is a diuretic that helps the body get rid of excess salt and water.

Warnings and Precautions

Are there harms and risks from taking combination of Amlodipine and Indapamide?

Common side effects of Amlodipine include swelling of the ankles or feet, dizziness, and flushing. Indapamide may cause side effects such as low potassium levels, dizziness, and fatigue. Both medications can cause dizziness, especially when standing up quickly, due to their blood pressure-lowering effects. Serious adverse effects, though rare, can include severe allergic reactions, significant drops in blood pressure, or electrolyte imbalances. Patients should report any unusual symptoms to their healthcare provider promptly.

Can I take combination of Amlodipine and Indapamide with other prescription drugs?

Amlodipine can interact with other blood pressure medications, leading to an excessive drop in blood pressure. It may also interact with certain heart medications, such as beta-blockers. Indapamide can interact with other diuretics and medications that affect electrolyte balance, increasing the risk of imbalances. Both drugs can interact with non-steroidal anti-inflammatory drugs (NSAIDs), which may reduce their effectiveness. Patients should always inform their healthcare provider of all medications they are taking to manage potential interactions.

Can I take combination of Amlodipine and Indapamide if I am pregnant?

Amlodipine is generally not recommended during pregnancy unless absolutely necessary, as there is limited data on its safety. Indapamide is also typically avoided during pregnancy due to potential risks to the fetus, including electrolyte imbalances. Both medications should only be used if the potential benefits justify the risks. Pregnant women should discuss their treatment options with their healthcare provider to ensure the safety of both mother and child.

Can I take combination of Amlodipine and Indapamide while breastfeeding?

Amlodipine is generally considered safe during breastfeeding, as only small amounts are excreted in breast milk. However, caution is advised, and monitoring the infant for any adverse effects is recommended. Indapamide's safety during breastfeeding is less clear, and it may affect milk production due to its diuretic effect. Mothers should consult their healthcare provider to weigh the benefits and risks of using these medications while breastfeeding and consider alternative treatments if necessary.

Who should avoid taking combination of Amlodipine and Indapamide?

Amlodipine should be used with caution in patients with severe heart conditions, as it can affect heart rate and rhythm. Indapamide is contraindicated in patients with severe kidney disease or electrolyte imbalances. Both medications should be used cautiously in patients with liver disease. Patients should avoid abrupt discontinuation of these medications, as it can lead to a rebound increase in blood pressure. Regular monitoring and communication with a healthcare provider are crucial to manage these risks.