Lace Suspension (LACTULOSE)

What is Lace suspension?

Lace suspension is a medicine that helps with constipation. It helps you poop more often by making your bowel movements softer. The medicine stays in your intestines and doesn't enter your bloodstream.

What is the usual dose of Lace suspension?

The typical dose for adults is 15-30 mL daily, containing 10-20 g of Lace suspension. The dose may be increased to 60 mL daily if necessary. For children, specific dosage guidance is not detailed.

How do I take Lace suspension?

• Dosage: Follow the dose prescribed by your doctor. It is usually taken once or twice daily.
• With or Without Food: Lace suspension can be taken with or without food. If it upsets your stomach, take it with meals.
• Food Restrictions: Generally, no specific food restrictions are required. However, maintain a balanced diet and drink plenty of fluids to aid its effects.
• Other Tips: Avoid overuse as it may cause diarrhea. Contact a doctor if you experience severe side effects.

For how long do I take Lace suspension?

Use Lace suspension as directed by your physician. It may be used long-term for chronic constipation, but periodic monitoring is advised for prolonged use.

What is Lace suspension used for?

Constipation:

• Used to treat chronic or occasional constipation by softening stools and improving bowel movements.

Hepatic Encephalopathy (HE):

• Helps reduce ammonia levels in patients with liver disease to prevent or treat confusion, drowsiness, or coma caused by HE.

Other Possible Uses (off-label):

• Certain bowel disorders requiring stool softening, as determined by a doctor.

How long does it take for Lace suspension to start working?

Lace suspension typically takes 24 to 48 hours to produce a bowel movement when used for constipation. For hepatic encephalopathy, its effects may begin within 24 hours but may take longer to fully regulate ammonia levels. Ensure consistent dosing as prescribed for the best results.

Is Lace suspension effective?

1. Constipation: Clinical trials show Lace suspension improves stool frequency and consistency within 24–48 hours, making it effective for chronic and acute cases.
2. Hepatic Encephalopathy: Studies confirm Lace suspension reduces ammonia levels, improves mental status, and prevents HE episodes in liver disease patients.
3. Safety and Tolerability: Proven safe for long-term use, with mild side effects like gas or bloating.

How does one know if Lace suspension is working?

For Constipation:

• Frequency: Increased regular bowel movements.
• Consistency: Softer stools, easier to pass.
• Relief: Reduced discomfort from constipation symptoms.

For Hepatic Encephalopathy:

• Ammonia Levels: Reduced ammonia in blood tests.
• Cognitive Function: Improved mental clarity and reduced confusion.
• Prevention: Fewer HE episodes.

How does Lace suspension work?

1. Constipation: Pulls water into the colon, softening stool and promoting bowel movements.
2. Hepatic Encephalopathy: Reduces ammonia in the blood by converting it into a non-toxic form excreted in stool.

Who should avoid taking Lace suspension?

• Electrolyte Imbalance: Prolonged use or high doses may cause dehydration and imbalances in sodium and potassium.
• Abdominal Issues: Use with caution in patients with gastrointestinal issues like bowel obstruction, irritable bowel syndrome (IBS), or galactose intolerance.
• Monitor in Liver Disease: Adjust dosage carefully in hepatic encephalopathy patients to avoid overuse.

Contraindications:

• Bowel Obstruction: Should not be used in cases of severe or unknown bowel obstruction.
• Galactosemia: Contraindicated in patients with this rare inherited disorder.

Can I take Lace suspension with vitamins or supplements?

Electrolyte Supplements:

• Lace suspension can cause dehydration or electrolyte imbalances (low potassium or sodium). If taking supplements like potassium, monitor levels closely.

Magnesium:

• Combining Lace suspension with magnesium-containing supplements may increase the risk of diarrhea and dehydration.

Vitamins:

• Long-term use may reduce absorption of certain vitamins (e.g., Vitamin K, calcium), especially if it causes diarrhea.

Can I take Lace suspension with other prescription drugs?

Lace suspension may interact with diuretics (increasing the risk of electrolyte imbalances), antibiotics (affecting gut bacteria and Lace suspension’s efficacy in treating hepatic encephalopathy), other laxatives (causing dehydration or excessive diarrhea), and corticosteroids (increasing electrolyte disturbances). Always inform your doctor about other medications to avoid harmful interactions and ensure proper use of Lace suspension.

Can Lace suspension be taken safely while pregnant?

Lace suspension is generally considered safe during pregnancy, as it is not absorbed into the bloodstream and acts locally in the gut. There is no evidence of fetal harm from its use. However, it should only be used during pregnancy when clearly needed, and the benefits should be weighed against any potential risks. Always consult a healthcare provider before using Lace suspension during pregnancy.

Can Lace suspension be taken safely while breastfeeding?

Lace suspension is considered safe during lactation. It is not absorbed into the bloodstream in significant amounts, so it is unlikely to affect breast milk or harm the baby. However, it's always best to consult a healthcare provider before using any medication while breastfeeding, to ensure it’s appropriate based on individual circumstances.

Is Lace suspension safe for the elderly?

Elderly patients on Lace suspension for over six months should have periodic serum electrolyte monitoring to prevent imbalances, their blood needs to be tested regularly to check the levels of potassium, chloride, and carbon dioxide. These tests are important because Lace suspension can sometimes affect these levels. Also, some antacids can stop Lace suspension from working properly.

How should I store Lace suspension?

Lace suspension should be stored at room temperature between 68°F to 77°F (20°C to 25°C). Do not freeze it. Keep the medicine away from heat and light. If the medicine turns dark, cloudy, or becomes too thick to pour, do not use it. Always ensure the bottle is tightly closed and store it in a cool, dry place, out of reach of children.

Does Lace suspension make people tired or drowsy?

Fatigue or drowsiness is not listed as a common side effect of Lace suspension.

Does Lace suspension cause stomach upset?

Flatulence and cramps are common initially. If severe, reduce the dose or consult a doctor.

Does Lace suspension affect sleep?

There is no evidence suggesting that Lace suspension affects sleep.

Does Lace suspension make it hard to think or concentrate?

Lace suspension does not commonly cause cognitive effects such as difficulty concentrating.

Does Lace suspension affect mood?

Mood alterations are not reported as a side effect of Lace suspension.

Does Lace suspension interfere with sexual function?

No effects on sexual function are mentioned .

Does Lace suspension affect appetite?

Appetite changes are not reported as a side effect of Lace suspension.

Does Lace suspension cause weight gain?

Weight gain is not associated with Lace suspension use.

Does Lace suspension cause headaches?

Lace suspension usually doesn't cause headaches. The most common problems are gas and stomach cramps at first, and diarrhea if you take too much. Severe diarrhea can lead to dehydration and other problems, so stop taking it if that happens. Some people also get sick to their stomach.

Does Lace suspension limit driving?

No, Lace suspension does not impair driving ability.

Is it safe to drink alcohol while taking Lace suspension?

Interactions with alcohol is not known, but general caution is advised.

Is it safe to drink coffee or tea while taking Lace suspension?

Coffee or tea is not contraindicated with Lace suspension use.

Is it safe to exercise while taking Lace suspension?

Yes, exercising while taking Lace suspension is safe unless side effects such as diarrhea cause discomfort. Consult your doctor if symptoms interfere with activity.

What are Lace suspension possible harms and risks?

Common Side Effects:

• Bloating
• Gas (flatulence)
• Abdominal cramping
• Diarrhea (with high doses)

Significant Adverse Effects:

• Severe dehydration or electrolyte imbalance (due to prolonged diarrhea).
• Worsened abdominal pain or bloating.