Daramin 25mg Tablet (PYRIMETHAMINE)
What is Daramin tablet?
Daramin tablet is an antiparasitic medication used primarily to treat toxoplasmosis, often in combination with a sulfonamide. It works by inhibiting folic acid metabolism in parasites, which is essential for their growth and reproduction. This action is highly selective against the parasites, making it effective in treating infections.
What is the usual dose of Daramin tablet?
For adults, the usual daily dose of Daramin tablet is 50 to 75 mg, taken with a sulfonamide. For children, the dose is 1 mg/kg/day, divided into two equal daily doses. After 2 to 4 days, this dose may be reduced to half and continued for about a month. Always follow your doctor's specific instructions.
How do I take Daramin tablet?
Daramin tablet can be taken with meals to minimize gastrointestinal side effects like vomiting. There are no specific food restrictions mentioned, but always follow your doctor's instructions and consult them for personalized advice.
For how long do I take Daramin tablet?
Daramin tablet is typically used for 1 to 3 weeks initially, depending on the patient's response and tolerance. The dosage may then be reduced and continued for an additional 4 to 5 weeks. Always follow your doctor's specific instructions.
What disease or symptom is Daramin tablet used for?
Daramin tablet is primarily indicated for the treatment of toxoplasmosis, especially when used in combination with a sulfonamide. It is effective in treating infections caused by the Toxoplasma parasite.
How long does it take for Daramin tablet to start working?
Daramin tablet is well absorbed, with peak levels occurring between 2 to 6 hours after administration. However, the time it takes to notice an improvement in symptoms can vary. Always consult a healthcare provider for personalized advice.
Is Daramin tablet effective?
Daramin tablet is an antiparasitic medication that works by inhibiting folic acid metabolism in parasites like Toxoplasma. Its effectiveness is enhanced when used with sulfonamides, as demonstrated in studies on experimental toxoplasmosis in mice and rabbits. Always consult a healthcare provider for personalized advice.
How do I know if Daramin tablet is working?
The benefit of Daramin tablet is evaluated by monitoring the patient's response to treatment, including symptom improvement and tolerance to the medication. Regular blood tests may be conducted to check for side effects, especially in high doses. Always consult a healthcare provider for personalized advice.
How does Daramin tablet work?
Daramin tablet works by inhibiting the enzyme dihydrofolate reductase, which is crucial for folic acid metabolism in parasites. This inhibition prevents the parasites from synthesizing nucleic acids necessary for their growth and reproduction, effectively controlling the infection.
Who should avoid taking Daramin tablet?
Daramin tablet is contraindicated in patients with hypersensitivity to the drug or its components, and in those with megaloblastic anemia due to folate deficiency. It has a narrow therapeutic window, and folate deficiency signs require dosage adjustment or discontinuation. It may be carcinogenic and should be kept out of children's reach due to overdose risks. Always consult a healthcare provider for personalized advice.
Can I take Daramin tablet with other prescription drugs?
Daramin tablet may interact with sulfonamides, quinine, and other antimalarials. It can increase the risk of bone marrow suppression when used with antifolic drugs or agents associated with myelosuppression, such as methotrexate. Mild hepatotoxicity has been reported with lorazepam. Always consult a healthcare provider for personalized advice.
Can Daramin tablet be taken safely while pregnant?
Daramin tablet should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It has been shown to be teratogenic in animal studies. Concurrent administration of folinic acid is strongly recommended during pregnancy. Always consult a healthcare provider for personalized advice.
Can Daramin tablet be taken safely while breastfeeding?
Daramin tablet is excreted in human milk, and due to potential serious adverse reactions in nursing infants, a decision should be made to either discontinue nursing or the drug. Always consult a healthcare provider for personalized advice.
Is Daramin tablet safe for the elderly?
For elderly patients, dose selection should be cautious, usually starting at the low end of the dosing range. This is due to the greater frequency of decreased hepatic, renal, or cardiac function, and the presence of other diseases or drug therapies. Always consult a healthcare provider for personalized advice.
How should I store Daramin tablet?
Daramin tablet should be stored at a temperature between 15° to 25°C (59° to 77°F) in a dry place and protected from light. Always keep it out of reach of children.
Does Daramin tablet cause stomach upset?
Common gastrointestinal side effects of Daramin tablet include nausea and vomiting. Vomiting can be minimized by taking the medication with meals. If these side effects persist or worsen, it is important to consult a healthcare provider for advice.
Does Daramin tablet affect appetite?
Daramin tablet may cause anorexia, which is a decreased appetite. If you experience a significant change in appetite, it is important to consult a healthcare provider for advice.
What are Daramin tablet possible harms and risks?
Common side effects of Daramin tablet include anorexia and vomiting. Serious adverse effects can include hypersensitivity reactions, megaloblastic anemia, leukopenia, and thrombocytopenia. If you experience any severe side effects, seek medical attention immediately.
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